Seed J R, Sechelski J, Hall J E
Department of Parasitology and Laboratory Practice, School of Public Health, University of North Carolina, Chapel Hill 27514.
Am J Trop Med Hyg. 1987 Sep;37(2):314-9. doi: 10.4269/ajtmh.1987.37.314.
Tyrosine aminotransferase (TAT), glutamic-pyruvic transaminase (GPT), glutamic-oxaloacetic transaminase (GOT), and alkaline phosphatase (ALP) were measured in the serum and livers of Microtus montanus infected with Trypanosoma brucei gambiense. Only liver TAT and serum ALP showed significant changes. In addition, blood glucose, pyruvate and lactate, and liver glycogen levels were assayed. All four compounds showed significant changes, strongly suggesting increased glycogen mobilization and increased catabolic activity. Interestingly, the serum ketone levels were very low and no significant changes were observed. These chronically infected animals had an organic aciduria in which pyruvate, lactate, beta-hydroxybutyrate, alpha-ketoglutarate, phenylpyruvate, and p-hydroxyphenylpyruvate were significantly increased. The possible significance of these observations is discussed.
在感染了布氏冈比亚锥虫的蒙塔努斯田鼠的血清和肝脏中，测定了酪氨酸转氨酶（TAT）、谷丙转氨酶（GPT）、谷草转氨酶（GOT）和碱性磷酸酶（ALP）。只有肝脏TAT和血清ALP出现了显著变化。此外，还测定了血糖、丙酮酸和乳酸以及肝脏糖原水平。所有这四种化合物都出现了显著变化，强烈表明糖原动员增加和分解代谢活性增强。有趣的是，血清酮水平非常低，未观察到显著变化。这些慢性感染的动物出现了有机酸尿症，其中丙酮酸、乳酸、β-羟基丁酸、α-酮戊二酸、苯丙酮酸和对羟基苯丙酮酸显著增加。讨论了这些观察结果可能的意义。
