Gąsior Łukasz, Daszkiewicz Regina, Ogórek Mateusz, Polański Zbigniew
Zakład Genetyki i Ewolucjonizmu, Instytut Zoologii, Wydział Biologii i Nauk o Ziemi, Uniwersytet Jagielloński w Krakowie.
Postepy Hig Med Dosw (Online). 2017 Jan 4;71(1):690-702. doi: 10.5604/01.3001.0010.3848.
In most animal species female germ cells are the source of mitochondrial genome for the whole body of individuals. As a source of mitochondrial DNA for future generations the mitochondria in the female germ line undergo dynamic quantitative and qualitative changes. In addition to maintaining the intact template of mitochondrial genome from one generation to another, mitochondrial role in oocytes is much more complex and pleiotropic. The quality of mitochondria determines the ability of meiotic divisions, fertilization ability, and activation after fertilization or sustaining development of a new embryo. The presence of normal number of functional mitochondria is also crucial for proper implantation and pregnancy maintaining. This article addresses issues of mitochondrial role and function in mammalian oocyte and presents new approaches in studies of mitochondrial function in female germ cells.
在大多数动物物种中，雌性生殖细胞是个体全身线粒体基因组的来源。作为后代线粒体DNA的来源，雌性生殖系中的线粒体经历动态的数量和质量变化。除了将线粒体基因组的完整模板代代相传外，线粒体在卵母细胞中的作用更为复杂且具有多效性。线粒体的质量决定减数分裂的能力、受精能力以及受精后或新胚胎持续发育的激活能力。正常数量的功能性线粒体的存在对于正确着床和维持妊娠也至关重要。本文探讨了线粒体在哺乳动物卵母细胞中的作用和功能问题，并介绍了雌性生殖细胞线粒体功能研究的新方法。
