Hoffmann W E, Baker G, Rieser S, Dorner J L
Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Illinois, Urbana 61801.
Am J Vet Res. 1987 Sep;48(9):1343-7.
Effects of induced cholestasis and hepatocellular necrosis and of fasting on serum biochemical constituents including bile acids, IgA, bilirubin, alkaline phosphatase, gamma-glutamyltransferase (GGT), arginase, and the clearance of sodium sulfobromophthalein were studied in 4 groups of equids. The reference value for serum bile acids, as determined by an enzymatic colorimetric procedure for horses and ponies was 5.94 +/- 2.72 mumol/L, there being no statistical difference for horses and ponies. Sample collection at time of feeding had no effect on serum bile acid concentration. Seemingly, serum bile acids, arginase, and GGT were the most sensitive indicators of cholestasis and/or hepatocellular necrosis and would form an essential minimum effective battery of tests to diagnose and prognose hepatic disease in equids. These tests provided a measure of hepatobiliary transport function (bile acids), cell necrosis (arginase), and cholestasis (GGT and bile acids).
在4组马属动物中研究了诱导胆汁淤积、肝细胞坏死以及禁食对血清生化成分（包括胆汁酸、IgA、胆红素、碱性磷酸酶、γ-谷氨酰转移酶（GGT）、精氨酸酶）以及磺溴酞钠清除率的影响。采用酶比色法测定马和小马的血清胆汁酸参考值为5.94±2.72μmol/L，马和小马之间无统计学差异。采食时采集样本对血清胆汁酸浓度无影响。似乎血清胆汁酸、精氨酸酶和GGT是胆汁淤积和/或肝细胞坏死最敏感的指标，将构成诊断和预测马属动物肝脏疾病的基本最低有效检测组合。这些检测提供了对肝胆转运功能（胆汁酸）、细胞坏死（精氨酸酶）和胆汁淤积（GGT和胆汁酸）的一种衡量。
