Department of Biomedical Engineering, University of Houston, Houston, TX, USA.
Department of Physical Medicine and Rehabilitation, University of Texas Health Science Center - Houston, McGovern Medical School, and TIRR Memorial Hermann Research Center, Houston, TX, USA.
Sci Rep. 2017 Sep 11;7(1):11098. doi: 10.1038/s41598-017-11191-3.
The auditory evoked startle reflex is a conserved response resulting in neurological and motor activity. The presence of a mild prepulse immediately before the main pulse inhibits startle responses, though the mechanism for this remains unknown. In this study, the electroencephalography (EEG) data recorded from 15 subjects was analyzed to study the N1 and P2 components of cortical auditory evoked potentials (CAEPs) evoked by 70, 80, 90, 100, and 110 dB stimuli both in the presence and absence of 70 dB prepulses. Results without a prepulse showed an evolution of N1 amplitudes, increasing with stimulus intensity and showing largely significant differences. Results from prepulse trials only showed noteworthy changes in peak-to-peak amplitude in the 100 dB condition. Prepulse and non-prepulse conditions were then compared using peak amplitudes and theta power. Prepulse conditions significantly decreased the amplitude for both components in the 110 dB condition, i.e., pre-pulse inhibition, but significantly increased the N1 amplitude in the 70 dB condition, i.e., pre-pulse facilitation. Similarly theta band power significantly increased in the 70 dB prepulse condition and significantly decreased in the 110 dB prepulse condition. These results expand the basis of knowledge regarding how CAEPs change and elaborate on their neural function and representation.
听觉诱发惊跳反射是一种保守的反应，会导致神经系统和运动活动。在主脉冲之前立即出现轻度预脉冲会抑制惊跳反应，尽管其机制尚不清楚。在这项研究中，分析了 15 名受试者的脑电图 (EEG) 数据，以研究在存在和不存在 70dB 预脉冲的情况下，由 70、80、90、100 和 110dB 刺激诱发的皮质听觉诱发电位 (CAEP) 的 N1 和 P2 成分。没有预脉冲的结果显示 N1 振幅的演变，随着刺激强度的增加而增加，并且表现出很大的差异。仅在预脉冲试验中，在 100dB 条件下观察到峰峰值幅度的显著变化。然后使用峰幅度和θ功率比较预脉冲和非预脉冲条件。在 110dB 条件下，预脉冲条件显著降低了两个成分的幅度，即预脉冲抑制，但在 70dB 条件下，N1 幅度显著增加，即预脉冲促进。同样，在 70dB 预脉冲条件下θ带功率显著增加，在 110dB 预脉冲条件下显著降低。这些结果扩展了关于 CAEPs 如何变化的知识基础，并详细阐述了它们的神经功能和表示。
