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保乳治疗后早期乳腺癌女性中年龄与局部复发的相关性：一项荟萃分析。

The association of young age with local recurrence in women with early-stage breast cancer after breast-conserving therapy: a meta-analysis.

机构信息

Department of Breast Surgery, Zhejiang Cancer Hospital, Hangzhou, China.

出版信息

Sci Rep. 2017 Sep 11;7(1):11058. doi: 10.1038/s41598-017-10729-9.

DOI:10.1038/s41598-017-10729-9
PMID:28894168
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5593910/
Abstract

The aim of this meta-analysis is to determine the relationship between young age and local recurrence in patients with early-stage breast cancer after breast-conserving therapy. Eligible studies were retrieved from various electronic databases. Among the 19 studies included, 14 studies were analyzed for 5-year local recurrence rate and 8 studies for 10-year local recurrence rate using random effects models. Both results showed that young patients were at higher risk of local recurrence compared to old patients (5-year: RR = 2.64, 95% CI (1.94-3.60); 10-year: RR = 2.37, 95% CI (1.57-3.58)). Harbord's modified test showed the presence of publication bias in both 5- and 10-year local recurrence rates (P = 0.019 and P = 0.01, respectively). While the Trim and Fill analysis showed that the presence of publication bias did not affect the overall outcome of the 5-year local recurrence rate (RR = 2.21, 95% CI (1.62, 3.02)), it significantly affected the effect size of the 10-year local recurrence rate (RR = 1.47, 95% CI (0.96, 2.27)). Young age is a significant risk factor for local recurrence developed within 5 years of breast-conserving therapy in patients with early-stage breast cancer. Further high-quality studies are needed to elucidate the relationship between young age and the risk of local recurrence developed within 10 years.

摘要

本荟萃分析旨在确定保乳治疗后早期乳腺癌患者年龄与局部复发之间的关系。从各种电子数据库中检索到合格的研究。在纳入的 19 项研究中，有 14 项研究分析了 5 年局部复发率，8 项研究分析了 10 年局部复发率，使用随机效应模型。这两个结果均表明，年轻患者的局部复发风险高于老年患者（5 年：RR=2.64，95%CI（1.94-3.60）；10 年：RR=2.37，95%CI（1.57-3.58））。哈博德修正检验表明，5 年和 10 年局部复发率均存在发表偏倚（P=0.019 和 P=0.01）。虽然修剪和填充分析表明，发表偏倚的存在并未影响 5 年局部复发率的总体结果（RR=2.21，95%CI（1.62,3.02）），但它显著影响了 10 年局部复发率的效应量（RR=1.47，95%CI（0.96,2.27））。年轻是早期乳腺癌患者保乳治疗后 5 年内发生局部复发的显著危险因素。需要进一步开展高质量的研究来阐明年轻与 10 年内发生局部复发风险之间的关系。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3313/5593910/53eb52fa949b/41598_2017_10729_Fig12_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3313/5593910/eb2382d8916b/41598_2017_10729_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3313/5593910/a44114b2ec68/41598_2017_10729_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3313/5593910/c6eeda6acdb4/41598_2017_10729_Fig11_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3313/5593910/53eb52fa949b/41598_2017_10729_Fig12_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3313/5593910/a58fb2aa7f17/41598_2017_10729_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3313/5593910/2069ef5ed0a2/41598_2017_10729_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3313/5593910/1f76d2850406/41598_2017_10729_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3313/5593910/0f8b68f40674/41598_2017_10729_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3313/5593910/ce7c0e658355/41598_2017_10729_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3313/5593910/6bda99ea9eba/41598_2017_10729_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3313/5593910/fa0c4eb0a299/41598_2017_10729_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3313/5593910/87514dd75b91/41598_2017_10729_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3313/5593910/eb2382d8916b/41598_2017_10729_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3313/5593910/a44114b2ec68/41598_2017_10729_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3313/5593910/c6eeda6acdb4/41598_2017_10729_Fig11_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3313/5593910/53eb52fa949b/41598_2017_10729_Fig12_HTML.jpg

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