4-羟基苯甲醛对A型γ-氨基丁酸受体的作用
The Effect of 4-hydroxybenzaldehyde on the γ-aminobutyric Acid Type A Receptor.
作者信息
Zhang Jingli, Mohamad Habsah, Wong Jia Hui, Bilal Muhammad, Ismail Abdul Hadi Bin, Lloyd Amelia Jane, Yusoff Abdul Aziz Mohamed, Osman Hasnah, Wong Kok Tong, Idris Zamzuri, Abdullah Jafri Malin
机构信息
Department of Neurosciences, School of Medical Sciences, Universiti Sains Malaysia, Jalan Hospital Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia.
Institut Bioteknologi Marin, Universiti Malaysia Terengganu, 21030 Kuala Terengganu, Terengganu, Malaysia.
出版信息
Malays J Med Sci. 2017 Mar;24(2):94-99. doi: 10.21315/mjms2017.24.2.12. Epub 2017 Apr 14.
The αβγ subtype of GABA receptors is the most commonly found GABA receptor subtype in the mammalian cortex and hippocampus. It is expressed heterologously in the Xenopus laevis oocyte as a αβγS/L subtype for application as an in vitro model for the screening of compounds that modulate receptor activities. In fact, 4-hydroxybenzaldehyde (4-HB) has been identified as one of the major components in Dendrocalamus asper bamboo shoots in our previous study, and the current study showed that at 101.7 μM, 4-HB significantly reduced the GABA-induced chloride current of GABA receptors expressed on Xenopus oocytes, indicating a possible GABAergic antagonistic effect at high concentrations.
GABA受体的αβγ亚型是在哺乳动物皮层和海马体中最常见的GABA受体亚型。它在非洲爪蟾卵母细胞中作为αβγS/L亚型进行异源表达，用作筛选调节受体活性化合物的体外模型。事实上，在我们之前的研究中，4-羟基苯甲醛（4-HB）已被确定为麻竹竹笋中的主要成分之一，并且当前研究表明，在101.7 μM时，4-HB显著降低了非洲爪蟾卵母细胞上表达的GABA受体的GABA诱导的氯离子电流，表明在高浓度下可能具有GABA能拮抗作用。
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