女性的月经和生殖因素与胰腺癌风险
Menstrual and Reproductive Factors and Risk of Pancreatic Cancer in Women.
作者信息
Masoudi Sahar, Momayez Sanat Zahra, Mahmud Saleh Altun, Nozari Neda, Ghamarzad Neda, Pourshams Akram
机构信息
Digestive Oncology Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Liver and Pancreatobiliary Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
出版信息
Middle East J Dig Dis. 2017 Jul;9(3):146-149. doi: 10.15171/mejdd.2017.65.
BACKGROUND Pancreatic cancer (PC) is a deadly disease with a 5-year survival of less than 5%. Worldwide PC incidence rates are lower among women than men. While this suggests a protective role for steroid hormones in PC risk, results from epidemiological studies are not consistent. METHODS 153 new incident PC cases and 202 controls were recruited from a prospective case-control study, running in a referral center for endoscopic ultrasonography during 2011-2017. A structured valid and reliable questionnaire was used for data collection by a few trained interviewers. Odds ratios and 95% confidence intervals for reproductive factors and PC were estimated using logistic regression methods. RESULTS Mean age (SD) of the cases and the controls were 63.18 (11.4) and 63.37 (12.0) years, respectively. Age at menarche, age at menopause, number of parity, gravidity, and abortion were not associated with PC risk. CONCLUSION This study does not support the hypothesis that menstrual and reproductive factors are associated with PC risk.
背景
胰腺癌（PC）是一种致命疾病，5年生存率低于5%。在全球范围内，女性的胰腺癌发病率低于男性。虽然这表明甾体激素在胰腺癌风险中具有保护作用，但流行病学研究的结果并不一致。方法：从2011年至2017年在一家内镜超声检查转诊中心进行的一项前瞻性病例对照研究中招募了153例新发病例和202例对照。由几名经过培训的访谈员使用一份结构化的有效且可靠的问卷进行数据收集。使用逻辑回归方法估计生殖因素与胰腺癌的比值比和95%置信区间。结果：病例组和对照组的平均年龄（标准差）分别为63.18（11.4）岁和63.37（12.0）岁。初潮年龄、绝经年龄、产次、妊娠次数和流产次数与胰腺癌风险无关。结论：本研究不支持月经和生殖因素与胰腺癌风险相关的假设。
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