The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, China.
Technol Cancer Res Treat. 2020 Jan-Dec;19:1533033820962117. doi: 10.1177/1533033820962117.
This review aims to summarize the latest knowledge on factors, diagnosis, and treatment of pancreatic cancer, and aims to promote further research on this under-studied malignant tumor. At present, we urgently need to identify high-risk patients with precancerous diseases through screening approaches, so that medical professionals and the general public may better understand prevention strategies or early detection measures. Pancreatic cancer is a highly invasive malignant tumor with a fatal risk, mainly seen in men and older adults (60-85 years old). Pancreatic cancer is now increasingly observed in young patients. Because the disease has no early symptoms and can quickly invade surrounding tissues and organs, it is one of the deadliest cancers. With a view to identify the important factors for the development of pancreatic cancer, previous studies have found that smoking, alcohol, and chronic pancreatitis are considered high-risk factors. Recent studies have shown that abnormal metabolism of human microorganisms, blood type, and glucose and lipid levels are also important factors in the development of pancreatic cancer. Identifying early diagnosis options is an important way to improve detection and survival rates of pancreatic cancer. None of the many tumor markers associated with pancreatic cancer are highly specific, which also indicates further research is required to improve the early detection rate. Future directions in terms of treatment evaluating the relationship between the microbiology-free system and immunotherapy will bring a major breakthrough and is expected to bring exciting clinical applications in improving the life-cycle of pancreatic cancer patients.
本综述旨在总结胰腺癌相关因素、诊断和治疗的最新知识，旨在促进对这种研究不足的恶性肿瘤的进一步研究。目前，我们迫切需要通过筛查方法识别有癌前疾病的高危患者，以便医疗专业人员和公众更好地了解预防策略或早期检测措施。胰腺癌是一种具有致命风险的高度侵袭性恶性肿瘤，主要见于男性和老年人（60-85 岁）。目前，越来越多的年轻患者患有胰腺癌。由于该疾病没有早期症状，并且可以迅速侵袭周围组织和器官，因此它是最致命的癌症之一。为了确定胰腺癌发展的重要因素，先前的研究发现，吸烟、饮酒和慢性胰腺炎被认为是高危因素。最近的研究表明，人体微生物群、血型、血糖和血脂水平的异常代谢也是胰腺癌发展的重要因素。确定早期诊断选择是提高胰腺癌检测和生存率的重要途径。与胰腺癌相关的许多肿瘤标志物都没有高度特异性，这也表明需要进一步研究以提高早期检测率。未来在评估无微生物系统与免疫疗法之间的关系方面进行治疗评估，将带来重大突破，并有望在改善胰腺癌患者的生命周期方面带来令人兴奋的临床应用。
