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Should every Patient with MDS get Iron Chelation - Probably Yes.

作者信息

Ghosh Kanjaksha, Ghosh Kinjalka

机构信息

Surat Raktadan Kendra & research Centre, Gujrat, India.

Clinical Biochemistry, KEM Hospital & Seth GS Medical College Mumbai, India.

出版信息

Mediterr J Hematol Infect Dis. 2017 Sep 1;9(1):e2017055. doi: 10.4084/MJHID.2017.055. eCollection 2017.

DOI:10.4084/MJHID.2017.055
PMID:28894564
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5584764/
Abstract
摘要

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本文引用的文献

1
Iron-chelating therapy with deferasirox in transfusion-dependent, higher risk myelodysplastic syndromes: a retrospective, multicentre study.地拉罗司铁螯合疗法用于输血依赖型、高风险骨髓增生异常综合征：一项回顾性多中心研究
Br J Haematol. 2017 Jun;177(5):741-750. doi: 10.1111/bjh.14621. Epub 2017 Apr 17.
2
Myelodysplastic Syndromes and Iron Chelation Therapy.骨髓增生异常综合征与铁螯合疗法
Mediterr J Hematol Infect Dis. 2017 Mar 1;9(1):e2017021. doi: 10.4084/MJHID.2017.021. eCollection 2017.
3
Transplantation in thalassemia: Revisiting the Pesaro risk factors 25 years later.地中海贫血的移植：25年后重新审视佩萨罗风险因素
Am J Hematol. 2017 May;92(5):411-413. doi: 10.1002/ajh.24674. Epub 2017 Mar 22.
4
Management of iron overload in hemoglobinopathies: what is the appropriate target iron level?血红蛋白病中铁过载的管理：合适的目标铁水平是多少？
Ann N Y Acad Sci. 2016 Mar;1368(1):95-106. doi: 10.1111/nyas.13060.
5
Management of iron overload before, during, and after hematopoietic stem cell transplantation for thalassemia major.重型地中海贫血患者造血干细胞移植前、中、后铁过载的管理。
Ann N Y Acad Sci. 2016 Mar;1368(1):115-21. doi: 10.1111/nyas.13027. Epub 2016 Mar 21.
6
Transferrin facilitates the formation of DNA double-strand breaks via transferrin receptor 1: the possible involvement of transferrin in carcinogenesis of high-grade serous ovarian cancer.转铁蛋白通过转铁蛋白受体1促进DNA双链断裂的形成：转铁蛋白可能参与高级别浆液性卵巢癌的致癌过程。
Oncogene. 2016 Jul 7;35(27):3577-86. doi: 10.1038/onc.2015.425. Epub 2015 Nov 9.
7
Second international round robin for the quantification of serum non-transferrin-bound iron and labile plasma iron in patients with iron-overload disorders.铁过载疾病患者血清非转铁蛋白结合铁和不稳定血浆铁定量的第二次国际循环赛。
Haematologica. 2016 Jan;101(1):38-45. doi: 10.3324/haematol.2015.133983. Epub 2015 Sep 18.
8
Oxidative stress levels are correlated with P15 and P16 gene promoter methylation in myelodysplastic syndrome patients.氧化应激水平与骨髓增生异常综合征患者的P15和P16基因启动子甲基化相关。
Clin Exp Med. 2016 Aug;16(3):333-43. doi: 10.1007/s10238-015-0357-2. Epub 2015 May 17.
9
ROS-mediated iron overload injures the hematopoiesis of bone marrow by damaging hematopoietic stem/progenitor cells in mice.活性氧介导的铁过载通过损伤小鼠造血干/祖细胞来损害骨髓造血。
Sci Rep. 2015 May 13;5:10181. doi: 10.1038/srep10181.
10
Effects of iron overload on the bone marrow microenvironment in mice.铁过载对小鼠骨髓微环境的影响。
PLoS One. 2015 Mar 16;10(3):e0120219. doi: 10.1371/journal.pone.0120219. eCollection 2015.