Department of Dermatology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Biomed Res Int. 2017;2017:3571861. doi: 10.1155/2017/3571861. Epub 2017 Aug 15.
The role of factor XIII subunit A (FXIII-A) is not restricted to hemostasis. FXIII-A is also present intracellularly in several human cells and serves as a diagnostic marker in a wide range of dermatological diseases from inflammatory conditions to malignancies. In this review, we provide a guide on the still controversial interpretation of dermal cell types expressing FXIII-A and assess the previously described mechanisms behind their accumulation under physiological and pathological conditions of the human skin. We summarize the intracellular functions of FXIII-A as well as its possible sources in the extracellular space of the dermis with a focus on its relevance to skin homeostasis and disease pathogenesis. Finally, the potential role of FXIII-A in wound healing, as a field with long-term therapeutic implications, is also discussed.
FXIII-A 亚单位在止血中的作用不仅如此。FXIII-A 也存在于几种人类细胞的细胞内，并作为广泛的皮肤科疾病（从炎症性疾病到恶性肿瘤）的诊断标志物。在这篇综述中，我们提供了一个关于仍然存在争议的皮肤细胞类型表达 FXIII-A 的解释指南，并评估了其在生理和病理条件下在人类皮肤中积累的先前描述的机制。我们总结了 FXIII-A 的细胞内功能及其在真皮细胞外空间中的可能来源，重点是其与皮肤动态平衡和疾病发病机制的相关性。最后，还讨论了 FXIII-A 在伤口愈合中的潜在作用，因为这是一个具有长期治疗意义的领域。
