Shinebaum R, Neumann V C, Cooke E M, Wright V
Department of Medicine, General Infirmary, Leeds, UK.
Br J Rheumatol. 1987 Oct;26(5):329-33. doi: 10.1093/rheumatology/26.5.329.
The faecal flora of 25 out-patients with active rheumatoid arthritis (RA) was compared with that of 25 age- and sex-matched controls. A comprehensive survey revealed a significantly higher carriage rate of Clostridium perfringens in the RA population (88%) than controls (48%) (p less than 0.01). Coliform counts also tended to be higher, but there were no other significant differences between patients and controls. When the study was enlarged to include a further 113 RA patients with variable disease activity and a further 38 controls, clostridia were again more frequently carried by those with RA (70%) than controls (45%) (p less than 0.01) and clostridial counts were significantly higher in the patient group (p = 0.006). Moreover, counts in patients with active or moderately active disease were significantly higher than in those with inactive disease (p less than 0.001). These data are consistent with the hypothesis that Cl. perfringens plays a role in triggering or is otherwise associated with disease activity in RA. The findings may be alternatively an effect of the disease or its treatment with, for example, anti-inflammatory drugs.
将25名患有活动性类风湿性关节炎（RA）的门诊患者的粪便菌群与25名年龄和性别匹配的对照组的粪便菌群进行了比较。一项全面调查显示，RA患者中产气荚膜梭菌的携带率（88%）显著高于对照组（48%）（p<0.01）。大肠菌群计数也往往更高，但患者与对照组之间没有其他显著差异。当研究扩大到纳入另外113名疾病活动程度各异的RA患者和另外38名对照组时，RA患者携带梭菌的频率再次高于对照组（70%比45%）（p<0.01），并且患者组中的梭菌计数显著更高（p=0.006）。此外，患有活动性或中度活动性疾病的患者的计数显著高于无活动性疾病的患者（p<0.001）。这些数据与产气荚膜梭菌在触发RA疾病活动或与之有其他关联中起作用的假设一致。这些发现也可能是疾病本身或其治疗（例如使用抗炎药物）的一种效应。
