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Effects of sulphasalazine on faecal flora in patients with rheumatoid arthritis: a comparison with penicillamine.

作者信息

Neumann V C, Shinebaum R, Cooke E M, Wright V

机构信息

Department of Medicine, General Infirmary, Leeds, UK.

出版信息

Br J Rheumatol. 1987 Oct;26(5):334-7. doi: 10.1093/rheumatology/26.5.334.

DOI:10.1093/rheumatology/26.5.334
PMID:2889501
Abstract

Twenty-six out-patients with active rheumatoid arthritis (RA) were randomly allocated to treatment with sulphasalazine (SASP) or D-penicillamine (DPA). Faecal samples were collected from all patients at 4-weekly intervals and examined for changes in faecal flora during treatment. Both treatment groups showed substantial clinical improvement. In the SASP-treated group this was accompanied by significant falls in counts of Cl. perfringens and E. coli. No such changes were seen in the DPA-treated group. These results suggest that SASP's efficacy in RA may be related to its antibacterial properties.

摘要

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