Department of Basic Neuroscience, University of Geneva, Switzerland.
FEBS Lett. 2017 Dec;591(24):3960-3977. doi: 10.1002/1873-3468.12846. Epub 2017 Oct 16.
The adult neocortex is composed of several types of glutamatergic neurons, which are sequentially born from progenitors during development. The extent and nature of progenitor diversity, and how it relates to neuronal diversity, is still poorly understood. In this review, we discuss key features of neocortical progenitors across several species, including their morphological properties, cell cycling behaviour and molecular signatures, and how these features relate to the competence of these cells to generate distinct types of progenies.
成人大脑皮层由几种类型的谷氨酸能神经元组成，这些神经元在发育过程中依次由祖细胞产生。祖细胞的多样性的程度和性质，以及它与神经元多样性的关系，仍知之甚少。在这篇综述中，我们讨论了几种物种的大脑皮层祖细胞的关键特征，包括它们的形态特性、细胞周期行为和分子特征，以及这些特征如何与这些细胞产生不同类型后代的能力相关。
