Miller April, Sanderson Kristy, Bruno Raimondo, Breslin Monique, Neil Amanda L
Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia.
School of Health Sciences, University of East Anglia, Norwich, UK.
Pharmacoepidemiol Drug Saf. 2017 Nov;26(11):1403-1410. doi: 10.1002/pds.4301. Epub 2017 Sep 12.
Opioid analgesic use and associated adverse events have increased over the last 15 years, including in Australia. Whether this is associated with increased chronic pain prevalence in the Australian population is unknown. This study aimed to estimate (1) the prevalence of chronic pain and analgesia use in the Australian population by age and sex; (2) the severity of pain in the population with chronic pain by sex; and (3) the distribution of recent pain severity in those using analgesia by age and sex.
This study used cross-sectional, nationally representative data collected by the Australian Bureau of Statistics 2011 to 2012 National Health Survey. A total of n = 20 426 participants were included with an overall response rate of 84.8%. Weighting procedures were applied to obtain population estimates, confidence intervals, and when testing for statistical significance.
The prevalence of chronic and reoccurring pain (over a 6-month period) was 15.4% (2.75 million) for Australians aged ≥15 years. Prevalence increased with age for both sexes. Significantly more females reported moderate-to-very severe pain overall (P < 0.001), and within most age groups. Recent use of opioid analgesia was reported by 12.0% of males and 13.4% of females with chronic pain.
Chronic pain and opioid analgesic use are important public health issues in Australia. Study estimates of chronic pain and recent pain were no greater than earlier estimates. The acknowledged increase of opioid use in the literature thus appears consistent with changing treatment and/or prescribing patterns over time. Sex differences regarding pain prevalence, severity, and opioid use were apparent.
在过去15年中,阿片类镇痛药的使用及相关不良事件有所增加,澳大利亚亦是如此。这是否与澳大利亚人群中慢性疼痛患病率的增加有关尚不清楚。本研究旨在估计:(1)按年龄和性别划分的澳大利亚人群中慢性疼痛和镇痛药物使用情况的患病率;(2)按性别划分的慢性疼痛人群的疼痛严重程度;(3)按年龄和性别划分的使用镇痛药人群近期疼痛严重程度的分布情况。
本研究使用了澳大利亚统计局2011年至2012年国民健康调查收集的具有全国代表性的横断面数据。总共纳入了n = 20426名参与者,总体应答率为84.8%。采用加权程序来获得总体估计值、置信区间,并进行统计学显著性检验。
年龄≥15岁的澳大利亚人中,慢性和复发性疼痛(6个月期间)的患病率为15.4%(275万)。两性的患病率均随年龄增长而增加。总体而言,报告中度至非常严重疼痛的女性明显更多(P < 0.001),在大多数年龄组中亦是如此。慢性疼痛男性中12.0%、女性中13.4%报告近期使用过阿片类镇痛药。
慢性疼痛和阿片类镇痛药的使用是澳大利亚重要的公共卫生问题。本研究对慢性疼痛和近期疼痛的估计不高于早期估计。因此,文献中公认的阿片类药物使用增加似乎与治疗和/或处方模式随时间的变化一致。疼痛患病率、严重程度和阿片类药物使用方面的性别差异明显。