儿童黑色素瘤的病理学与基因组学：一次批判性重新审视及新见解
Pathology and genomics of pediatric melanoma: A critical reexamination and new insights.
作者信息
Bahrami Armita, Barnhill Raymond L
机构信息
Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee.
出版信息
Pediatr Blood Cancer. 2018 Feb;65(2). doi: 10.1002/pbc.26792. Epub 2017 Sep 12.
Abstract
The clinicopathologic features of pediatric melanoma are distinct from those of the adult counterpart. For example, most childhood melanomas exhibit a uniquely favorable biologic behavior, save for those arising in large/giant congenital nevi. Recent studies suggest that the characteristically favorable biologic behavior of childhood melanoma may be related to extreme telomere shortening and dysfunction in the cancer cells. Herein, we review the genomic profiles that have been defined for the different subtypes of pediatric melanoma and particularly emphasize the potential prognostic value of telomerase reverse transcriptase alterations for these tumors.
摘要
儿童黑色素瘤的临床病理特征与成人黑色素瘤不同。例如，大多数儿童黑色素瘤表现出独特的良好生物学行为，但发生于大/巨大先天性痣的黑色素瘤除外。最近的研究表明，儿童黑色素瘤特征性的良好生物学行为可能与癌细胞中极端的端粒缩短和功能障碍有关。在此，我们回顾已确定的不同亚型儿童黑色素瘤的基因组概况，并特别强调端粒酶逆转录酶改变对这些肿瘤的潜在预后价值。
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