The Russell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA.
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2018 May;10(3):e1496. doi: 10.1002/wnan.1496. Epub 2017 Sep 11.
Dendrimers or dendritic polymers are a class of compounds with great potential for nanomedical use. Some of their properties, including their rigidity, low polydispersity and the ease with which their surfaces can be modified make them particularly well suited for use as MRI diagnostic or theranostic agents. For the past 20 years, researchers have recognized this potential and refined dendrimer formulations to optimize these nanocarriers for a host of MRI applications, including blood pool imaging agents, lymph node imaging agents, tumor-targeted theranostic agents and cell tracking agents. This review summarizes the various types of dendrimers according to the type of MR contrast they can provide. This includes the metallic T , T and paraCEST imaging agents, and the non-metallic diaCEST and fluorinated ( F) heteronuclear imaging agents. This article is categorized under: Diagnostic Tools > In Vivo Nanodiagnostics and Imaging Implantable Materials and Surgical Technologies > Nanomaterials and Implants.
树状聚合物或树枝状聚合物是一类具有巨大的纳米医学应用潜力的化合物。它们的一些特性，包括刚性、低多分散性以及易于修饰其表面，使它们特别适合用作 MRI 诊断或治疗药物。在过去的 20 年中，研究人员已经认识到了这一潜力，并改进了树状聚合物配方，以优化这些纳米载体在多种 MRI 应用中的性能，包括血池成像剂、淋巴结成像剂、肿瘤靶向治疗药物和细胞示踪剂。这篇综述根据它们能够提供的磁共振对比类型，对各种类型的树状聚合物进行了总结。这包括金属 T1、T2 和 paraCEST 成像剂，以及非金属 diaCEST 和氟化 (F) 异核成像剂。本文归入：诊断工具 > 体内纳米诊断和成像 可植入材料和手术技术 > 纳米材料和植入物。
