Baba Yusuke, Kaneko Hiyori, Takemoto Minoru, Ide Kana, Haga Yuki, Kanda Tatsuo, Akita Shinsuke, Kubota Yoshitaka, Kuroda Masayuki, Kitagawa Yutaka, Yokote Koutaro
Department of Clinical Cell Biology and Medicine, Chiba University Graduate School of Medicine, Chiba, Japan.
Department of Medicine, Division of Diabetes, Metabolism and Endocrinology, International University of Health and Welfare, Narita, Japan.
J Diabetes Investig. 2017 Sep 12;9(3):632-5. doi: 10.1111/jdi.12745.
Lipodystrophy is a rare condition that is often accompanied by one or more metabolic diseases. Here, we report a case of lipoatrophic diabetes induced by juvenile dermatomyositis. Although pioglitazone was not effective for lowering blood glucose levels, our observation suggested that it improved liver function slightly. The effectiveness of metreleptin for lowering blood glucose levels could not be determined, as we administered it in a short period. Liver biopsy showed burned-out non-alcoholic steatohepatitis. The present results show that the successful treatment of lipoatrophic diabetes induced by juvenile dermatomyositis requires an early diagnosis and therapeutic intervention.
脂肪营养不良是一种罕见的病症，常伴有一种或多种代谢性疾病。在此，我们报告一例由幼年皮肌炎诱发的脂肪萎缩性糖尿病病例。尽管吡格列酮对降低血糖水平无效，但我们的观察表明它能轻微改善肝功能。由于我们使用米泊美生的时间较短，因此无法确定其降低血糖水平的有效性。肝脏活检显示为终末期非酒精性脂肪性肝炎。目前的结果表明，成功治疗由幼年皮肌炎诱发的脂肪萎缩性糖尿病需要早期诊断和治疗干预。
