[从喜树内生真菌Diaporthe sp. XZ-07中分离得到的两种新内酯衍生物]
[Two new lactone derivatives from an endophyte Diaporthe sp. XZ-07 cultivated on Camptotheca acuminata].
作者信息
Shi Cheng, Yuan Lin, Lin Xiang, Zhao Pei-Ji
机构信息
Chemical Science and Technology Department, Kunming University, Kunming 650214, China.
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China.
出版信息
Zhongguo Zhong Yao Za Zhi. 2016 May;41(10):1860-1863. doi: 10.4268/cjcmm20161016.
To study the secondary metabolites and their cytotoxic activities of an endophytic fungus Diaporthe sp. XZ-07cultivated on Camptotheca acuminata. Colum chromatography by RP-18, Sephadex LH-20 and silica gel was used to isolate and purify the chemical constituent. Two new compounds were isolatedand identified as 5-((E)-1,4,5-trihydroxyhex-2-enyl)furan-2(5H)-one(1)and(5Z)-5-(2,3,4,5-tetrahydroxyhexylidene)furan-2(5H)-one(2)by spectroscopic analysis. Cytotoxic activities were evaluated by MTT method. Compound 1 showed strong inhibitory activity against Human cervical carcinoma cell line Hela, and compound 2 showed strong inhibitory activity against breast cancer cell line MCF-7, Human neuroblastoma SH-SY5Y and Lewis lung carcinoma cells 3LL.
研究喜树内生真菌Diaporthe sp. XZ-07的次生代谢产物及其细胞毒活性。采用RP-18、葡聚糖凝胶LH-20和硅胶柱色谱法分离纯化化学成分。通过光谱分析分离并鉴定出两个新化合物，分别为5-((E)-1,4,5-三羟基己-2-烯基)呋喃-2(5H)-酮(1)和(5Z)-5-(2,3,4,5-四羟基亚己基)呋喃-2(5H)-酮(2)。采用MTT法评估细胞毒活性。化合物1对人宫颈癌细胞系Hela表现出较强的抑制活性，化合物2对乳腺癌细胞系MCF-7、人神经母细胞瘤SH-SY5Y和Lewis肺癌细胞3LL表现出较强的抑制活性。
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