Two new compounds of , an endophytic fungus from Decne.

To discover novel structural compounds which are producted by endophytic fungi, a primary chemical profiling of Decne derived endophytic fungus had been taken. Two new compounds β-lactone polonicin A () and enoic acid polonicin B () together with seven known compounds - were isolated from obtained from . The structures of the new compounds and were identified by modern spectrum technology including detailed 1D, 2D NMR and MS data analyses. When tested against HepG2 hepatocellular carcinoma (HCC) cell lines, compounds - showed moderate anti-HCC activity. In addition, compound - have effects on increasing GLUT4 translocation and glucose uptake . Compound showed the strongest glucose uptake and GLUT4 translocation activities in rat skeleton (L6) myoblast cell line with enhancements of 1.8 and 2.1 folds respectively compared to the control.