School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, China.
School of Life Sciences, South-Central University for Nationalities, Wuhan, China.
Nat Prod Res. 2020 Jul;34(13):1879-1883. doi: 10.1080/14786419.2019.1569003. Epub 2019 Feb 13.
To discover novel structural compounds which are producted by endophytic fungi, a primary chemical profiling of Decne derived endophytic fungus had been taken. Two new compounds β-lactone polonicin A () and enoic acid polonicin B () together with seven known compounds - were isolated from obtained from . The structures of the new compounds and were identified by modern spectrum technology including detailed 1D, 2D NMR and MS data analyses. When tested against HepG2 hepatocellular carcinoma (HCC) cell lines, compounds - showed moderate anti-HCC activity. In addition, compound - have effects on increasing GLUT4 translocation and glucose uptake . Compound showed the strongest glucose uptake and GLUT4 translocation activities in rat skeleton (L6) myoblast cell line with enhancements of 1.8 and 2.1 folds respectively compared to the control.
为了发现内生真菌产生的新型结构化合物，对 Decne 来源的内生真菌进行了初步的化学成分分析。从 中分离得到的内生真菌 中分离得到了两个新化合物β-内酯 polonicin A ()和烯酸 polonicin B ()以及 7 个已知化合物 -。新化合物 和 的结构通过现代光谱技术确定，包括详细的 1D、2D NMR 和 MS 数据分析。在对 HepG2 肝癌 (HCC) 细胞系进行测试时，化合物 - 表现出中等的抗 HCC 活性。此外，化合物 - 对增加 GLUT4 易位和葡萄糖摄取有影响。与对照组相比，化合物 在大鼠骨骼 (L6) 成肌细胞系中表现出最强的葡萄糖摄取和 GLUT4 易位活性，分别增强了 1.8 和 2.1 倍。
