创伤性脑损伤小鼠模型中的骨骼肌萎缩和变性。
Skeletal Muscle Atrophy and Degeneration in a Mouse Model of Traumatic Brain Injury.
机构信息
1 Department of Orthopedic Surgery, University of California , San Diego, California.
2 Department of Anesthesiology, University of California , San Diego, California.
出版信息
J Neurotrauma. 2018 Jan 15;35(2):398-401. doi: 10.1089/neu.2017.5172. Epub 2017 Nov 3.
Abstract
Atrophy is thought to be a primary mode of muscle loss in neuromuscular injuries. The differential effects of central and peripheral injuries on atrophy and degeneration/regeneration in skeletal muscle tissue have not been well described. This study investigated skeletal muscle atrophy and degeneration/regeneration in an animal model of traumatic brain injury (TBI). Eight 8-month-old wild-type C57BL6 mice underwent either a sham craniotomy or TBI targeting the motor cortex. Atrophy (fiber area; FA) and degeneration/regeneration (centralized nuclei proportions; CN) of the soleus and tibialis anterior (TA) muscles were measured 2 months post-injury. Injured soleus FAs were smaller than sham soleus (p = 0.02) and injured TA (p < 0.001). Mean CNs were higher in the TBI-injured TA than in other muscles. Differential TBI-induced atrophy and degeneration/regeneration in lower limb muscles suggests that muscle responses to cortical injury involve more complex changes than those observed with simple disuse atrophy.
摘要
萎缩被认为是神经肌肉损伤中肌肉丢失的主要方式。中枢和外周损伤对骨骼肌组织萎缩和变性/再生的不同影响尚未得到很好的描述。本研究在创伤性脑损伤 (TBI) 的动物模型中研究了骨骼肌萎缩和变性/再生。8 只 8 月龄野生型 C57BL6 小鼠接受假手术或针对运动皮层的 TBI。受伤 2 个月后测量比目鱼肌和胫骨前肌 (TA) 的萎缩（纤维面积；FA）和变性/再生（中央核比例；CN）。受伤的比目鱼肌 FA 小于假手术比目鱼肌（p = 0.02）和受伤的 TA（p < 0.001）。TBI 损伤的 TA 中的平均 CN 高于其他肌肉。下肢肌肉中 TBI 诱导的萎缩和变性/再生的差异表明，肌肉对皮质损伤的反应涉及比单纯废用性萎缩更复杂的变化。
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