特应性皮炎患者的血清催乳素水平及其与疾病严重程度的关系。
Serum prolactin levels in atopic dermatitis and the relationship with disease severity.
作者信息
Tugrul Ayanoğlu Burcu, Muştu Koryürek Özgül, Yıldırm Başkara Songül
机构信息
Aksaray University, Aksaray Training and Research Hospital, Department of Dermatology and Venereology. Aksaray, Turkey.
出版信息
Arch Argent Pediatr. 2017 Oct 1;115(5):493-496. doi: 10.5546/aap.2017.eng.493.
BACKGROUND
Prolactin performs as a neuroendocrine modulator of skin epithelial cell proliferation and the skin immune system.
OBJETIVE
The aim was to assess the serum prolactin levels in patients with atopic dermatitis and the relationship with disease severity.
METHODS
The study was performed on 46 patients with atopic dermatitis and 100 healthy controls aged between 0.5 years and 19.5 years. The diagnosis of atopic dermatitis was based on clinical findings and the severity of the disease was documented. Venous blood sampling was performed in order to measure prolactin levels.
RESULTS
Prolactin levels in atopic dermatitis were not different from controls and there was no relationship between the severity of atopic dermatitis and serum prolactin levels. Prolactin may not have a role in the pathogenesis of atopic dermatitis. Further studies with larger sample sizes and measurement of prolactin levels in the skin may help to understand the role of prolactin in the pathogenesis of atopic dermatitis.
背景
催乳素作为一种神经内分泌调节剂，对皮肤上皮细胞增殖和皮肤免疫系统发挥作用。
目的
评估特应性皮炎患者的血清催乳素水平及其与疾病严重程度的关系。
方法
对46例年龄在0.5岁至19.5岁之间的特应性皮炎患者和100名健康对照者进行研究。特应性皮炎的诊断基于临床发现，并记录疾病的严重程度。为测量催乳素水平进行静脉血采样。
结果
特应性皮炎患者的催乳素水平与对照组无差异，且特应性皮炎的严重程度与血清催乳素水平之间无关联。催乳素可能在特应性皮炎的发病机制中不起作用。进一步开展更大样本量的研究以及测量皮肤中的催乳素水平，可能有助于了解催乳素在特应性皮炎发病机制中的作用。
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