Imoto Renata Robl, Uber Marjorie, Abagge Kerstin Taniguchi, Lima Mônica Nunes, Rosário Nelson Augusto, Carvalho Vânia Oliveira de
Pediatric Dermatologist at Hospital de Clínicas, Federal University of Paraná, Curitiba, Paraná, Brazil;
Pediatric Dermatologist at Hospital de Clínicas, Federal University of Paraná, Curitiba, Paraná, Brazil.
Allergol Immunopathol (Madr). 2021 Mar 1;49(2):66-71. doi: 10.15586/aei.v49i2.67. eCollection 2021.
BACKGROUND/OBJECTIVES: There is evidence that vitamin D (VD) supplementation may help in the management of atopic dermatitis (AD). The aim of this study was to assess the influence of VD supplementation on the severity of AD.
Pre-post interventional study with prospective data collection in patients younger than 14 years. The severity of AD was determined through SCORAD (SCORing Atopic Dermatitis) and classified as mild (SCORAD < 25), moderate (≥25 and <50), and severe (≥50). Skin prick test was performed in all patients. Serum VD levels were classified as sufficient (≥30 ng/mL), insufficient (29 to 21 ng/mL), and deficient (≤20 ng/mL); and those with inadequate levels received oral supplementation of VD for 3 months, and were reassessed after treatment.
A total of 152 patients were included. Patients with sufficient vitamin levels had lower SCORAD values (p = 0.04). Further, 116 patients (76.3%) received VD supplementation and after 3 months, VD levels were significantly higher (35.9 ng/mL) compared to baseline levels (23.7 ng/mL, p < 0.001). At the same time, a reduction in the SCORAD index was observed (19.4 before vs 12.3 after supplementation, p < 0.001). Considering other factors that could influence the decrease in AD severity after VD supplementation, female gender was associated with a worse treatment response (p = 0.02).
Vitamin D supplementation could be an adjuvant in reducing the severity of atopic dermatitis.
背景/目的：有证据表明补充维生素D（VD）可能有助于特应性皮炎（AD）的管理。本研究的目的是评估补充VD对AD严重程度的影响。
对14岁以下患者进行前瞻性数据收集的前后干预研究。通过特应性皮炎评分（SCORAD）确定AD的严重程度，并分为轻度（SCORAD<25）、中度（≥25且<50）和重度（≥50）。对所有患者进行皮肤点刺试验。血清VD水平分为充足（≥30 ng/mL）、不足（29至21 ng/mL）和缺乏（≤20 ng/mL）；VD水平不足的患者接受口服VD补充剂3个月，并在治疗后重新评估。
共纳入152例患者。维生素水平充足的患者SCORAD值较低（p = 0.04）。此外，116例患者（76.3%）接受了VD补充剂，3个月后，VD水平显著高于基线水平（35.9 ng/mL）（23.7 ng/mL，p < 0.001）。同时，观察到SCORAD指数降低（补充前为19.4，补充后为12.3，p < 0.001）。考虑到其他可能影响补充VD后AD严重程度降低的因素，女性的治疗反应较差（p = 0.02）。
补充维生素D可能是减轻特应性皮炎严重程度的辅助手段。
