气流阻塞与使用固体燃料烹饪或取暖：血氧水平依赖性功能磁共振成像结果
Airflow Obstruction and Use of Solid Fuels for Cooking or Heating: BOLD Results.
作者信息
Amaral André F S, Patel Jaymini, Kato Bernet S, Obaseki Daniel O, Lawin Hervé, Tan Wan C, Juvekar Sanjay K, Harrabi Imed, Studnicka Michael, Wouters Emiel F M, Loh Li-Cher, Bateman Eric D, Mortimer Kevin, Buist A Sonia, Burney Peter G J
机构信息
Imperial College London, NHLI - Respiratory Epidemiology, London, United Kingdom of Great Britain and Northern Ireland ;
Imperial College London, 4615, London, London, United Kingdom of Great Britain and Northern Ireland ;
出版信息
Am J Respir Crit Care Med. 2018 Mar 1;197(5):595-610. doi: 10.1164/rccm.201701-0205OC. Epub 2017 Sep 12.
RATIONALE
Evidence supporting the association of COPD or airflow obstruction with use of solid fuels is conflicting and inconsistent.
OBJECTIVE
To assess the association of airflow obstruction with self-reported use of solid fuels for cooking or heating.
METHODS
We analysed 18,554 adults from the BOLD study, who had provided acceptable post-bronchodilator spirometry measurements and information on use of solid fuels. The association of airflow obstruction with use of solid fuels for cooking or heating was assessed by sex, within each site, using regression analysis. Estimates were stratified by national income and meta-analysed. We carried out similar analyses for spirometric restriction, chronic cough and chronic phlegm.
MEASUREMENTS AND MAIN RESULTS
We found no association between airflow obstruction and use of solid fuels for cooking or heating (ORmen=1.20, 95%CI 0.94-1.53; ORwomen=0.88, 95%CI 0.67-1.15). This was true for low/middle and high income sites. Among never smokers there was also no evidence of an association of airflow obstruction with use of solid fuels (ORmen=1.00, 95%CI 0.57-1.76; ORwomen=1.00, 95%CI 0.76-1.32). Overall, we found no association of spirometric restriction, chronic cough or chronic phlegm with the use of solid fuels. However, we found that chronic phlegm was more likely to be reported among female never smokers and those who had been exposed for ≥20 years.
CONCLUSION
Airflow obstruction assessed from post-bronchodilator spirometry was not associated with use of solid fuels for cooking or heating.
原理
支持慢性阻塞性肺疾病（COPD）或气流受限与使用固体燃料之间存在关联的证据相互矛盾且不一致。
目的
评估气流受限与自我报告的烹饪或取暖使用固体燃料之间的关联。
方法
我们分析了来自BOLD研究的18554名成年人，他们提供了可接受的支气管扩张剂后肺功能测量值以及固体燃料使用信息。在每个研究地点，按性别通过回归分析评估气流受限与烹饪或取暖使用固体燃料之间的关联。估计值按国民收入分层并进行荟萃分析。我们对肺功能受限、慢性咳嗽和慢性咳痰进行了类似分析。
测量结果与主要结果
我们发现气流受限与烹饪或取暖使用固体燃料之间无关联（男性OR = 1.20，95%置信区间0.94 - 1.53；女性OR = 0.88，95%置信区间0.67 - 1.15）。在低收入/中等收入和高收入地区均如此。在从不吸烟者中，也没有证据表明气流受限与使用固体燃料有关联（男性OR = 1.00，95%置信区间0.57 - 1.76；女性OR = 1.00，95%置信区间0.76 - 1.32）。总体而言，我们发现肺功能受限、慢性咳嗽或慢性咳痰与使用固体燃料之间无关联。然而，我们发现女性从不吸烟者以及暴露≥20年者更有可能报告有慢性咳痰。
结论
支气管扩张剂后肺功能测量评估的气流受限与烹饪或取暖使用固体燃料无关。
Zotero 插件