Bicíková L
Cor Vasa. 1978;20(3):184-95.
Clinical measurements were made of the effects of various drugs on the stimulation threshold of human heart [right ventricle]. Of antiarrhythmic drugs, a marked and prolonged elevation of the stimulation threshold was produced by procainamide, quinidine, and aimaline. Relatively short-lasting elevation was elicited by local anaesthetics [trimecaine, lidocaine]. Beta-blockers were little effective. No detectable effect on the stimulation threshold was produced by phenytoin and digitalis glucosides from the group of antiarrhythmics. The deepest and most prolonged depression of the stimulation threshold was achieved with anabolics [nandrolone phenylpropionate, nandrolone decanoate] and with high doses of prednisone and of 6-methylprednisolone sodium succinate. Hydrocortisone was ineffective. A slight and brief depression was produced by atrophine. The effects of sympathomimetics were complicated: at stimulation with short pulses the threshold was always raised. At stimulation with long pulses the effects were variable, mostly biphasic [occasionally triphasic]: a transitory depression of the stimulation threshold was followed by a marked elevation. The I-t curve's slope altered. In exit block, sympathomimetics are indicated because of their chronotropic effect, not because of their questionable effect on the stimulation threshold. A number of drugs, often administered to stimulated patients, produced no effect on the stimulation threshold: antibiotics, nitrites, purine compounds, opiates, and others.
对各种药物对人心脏[右心室]刺激阈值的影响进行了临床测量。在抗心律失常药物中，普鲁卡因酰胺、奎尼丁和阿马林可使刺激阈值显著且持续升高。局部麻醉药[三甲卡因、利多卡因]可引起相对短暂的升高。β受体阻滞剂效果不佳。抗心律失常药组中的苯妥英和洋地黄糖苷对刺激阈值无明显影响。合成代谢类固醇[苯丙酸诺龙、癸酸诺龙]以及高剂量的泼尼松和琥珀酸钠甲泼尼龙可使刺激阈值出现最深且持续时间最长的降低。氢化可的松无效。阿托品可产生轻微且短暂的降低。拟交感神经药的作用较为复杂：短脉冲刺激时阈值总是升高。长脉冲刺激时作用多变，大多为双相[偶尔为三相]：刺激阈值短暂降低后显著升高。I-t曲线斜率改变。在传出阻滞中，使用拟交感神经药是因其变时作用，而非因其对刺激阈值的可疑作用。许多常用于受刺激患者的药物对刺激阈值无影响：抗生素、亚硝酸盐、嘌呤化合物、阿片类药物等。
