Doenecke V P
Fortschr Med. 1977 Jan 20;95(3):163-6.
Using the technical procedure of transvenous cardiac pacing right ventricular myocardium was stimulated with various pulse duration (voltage-duration curves) and with paired stimuli utilizing double pacing technique, to determine diastolic threshold profile up to the absolute refractory period. Two kinds of cardiac drugs were tested: Digitalis glycosides increase distolic excitability and shorten refractory period. Anitarrhythmic drugs have different effects: Lidocaine and Phenytoine in several cases decrease slightly the stimulatory threshold and can shorten the refractory period. Procainamide and Ajmaline prolong the refractory period and increase the stimulatory threshold. Propranolol and Verapamil have no significant effect. Their major action is supraventricular. The results are important in view of clinical pharmacology of cardiac drugs and of long term cardiac pacemaker therapy.
采用经静脉心脏起搏技术，用不同的脉冲持续时间（电压-持续时间曲线）刺激右心室心肌，并利用双起搏技术施加成对刺激，以确定直至绝对不应期的舒张期阈值曲线。测试了两种心脏药物：洋地黄糖苷可增加舒张期兴奋性并缩短不应期。抗心律失常药物有不同的作用：利多卡因和苯妥英钠在某些情况下会轻微降低刺激阈值并可缩短不应期。普鲁卡因胺和阿吗灵可延长不应期并提高刺激阈值。普萘洛尔和维拉帕米无显著作用，它们的主要作用是在室上性方面。鉴于心脏药物的临床药理学和长期心脏起搏器治疗，这些结果具有重要意义。
