基于含有二氟乙酰氧基配体的高价碘(III)试剂的光解实现杂芳环的直接 C-H 二氟甲基化反应。
The Direct C-H Difluoromethylation of Heteroarenes Based on the Photolysis of Hypervalent Iodine(III) Reagents That Contain Difluoroacetoxy Ligands.
机构信息
Department of Chemistry, Graduate School of Science, Kyoto University , Sakyo, Kyoto 606-8502, Japan.
出版信息
Org Lett. 2017 Oct 6;19(19):5126-5129. doi: 10.1021/acs.orglett.7b02416. Epub 2017 Sep 12.
PMID:28898083
Abstract
In this letter, an efficient method for the photolytic generation of difluoromethyl radicals from [bis(difluoroacetoxy)iodo]benzene reagents is described. The present approach enables the introduction of difluoromethyl groups into various heteroarenes under mild conditions in the absence of any additional reagents or catalysts.
摘要
在这封信中，描述了一种从[双（二氟乙酰氧基）碘]苯试剂中光解生成二氟甲基自由基的有效方法。本方法能够在温和条件下，无需任何额外试剂或催化剂，将二氟甲基基团引入各种杂芳烃中。
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