电化学氟甲基化反应在半水相条件下引发烯烃的内酯化反应。
Electrochemical fluoromethylation triggered lactonizations of alkenes under semi-aqueous conditions.
作者信息
Zhang Sheng, Li Lijun, Zhang Jinjin, Zhang Junqi, Xue Mengyu, Xu Kun
机构信息
Engineering Technology Research Center of Henan Province for Photo- and Electrochemical Catalysis , College of Chemistry and Pharmaceutical Engineering , Nanyang Normal University , Nanyang , 473061 , China . Email:
College of Life Science & Bioengineering , Beijing University of Technology , Beijing 100124 , China.
出版信息
Chem Sci. 2019 Feb 14;10(11):3181-3185. doi: 10.1039/c9sc00100j. eCollection 2019 Mar 21.
An electrochemical difluoromethylation triggered lactonization of alkenes was developed for the first time. This protocol employs readily prepared CFHSONa as the difluoromethylating reagent, affording unprecedented CFH-containing lactones in moderate yields. Moreover, with CFSONa as the trifluoromethylating reagent, a wide array of CF-containing lactones were obtained under additional supporting electrolyte- and catalyst-free conditions.
首次开发了一种电化学二氟甲基化引发的烯烃内酯化反应。该方法使用易于制备的CFHSONa作为二氟甲基化试剂，以中等产率得到了前所未有的含CFH的内酯。此外，以CFSONa作为三氟甲基化试剂，在无需额外支持电解质和催化剂的条件下得到了多种含CF的内酯。
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