Department of Applied Chemistry, China Agricultural University , Beijing 100193, P. R. China.
Org Lett. 2017 Oct 6;19(19):5236-5239. doi: 10.1021/acs.orglett.7b02512. Epub 2017 Sep 12.
An enantioselective synthesis of biologically important imidazolidines has been achieved via a tandem [3 + 2] cycloaddition/1,4-addition reaction of azomethine ylide and aza-o-quinone methides. With the use of this tool, various imidazolidine derivatives are obtained in good yields with excellent diastereoselectivities and enantioselectivities.
通过亚胺叶立德和氮杂-O-醌甲基化物的串联[3 + 2]环加成/1,4-加成反应，实现了具有重要生物学意义的咪唑烷的对映选择性合成。使用这种工具，可以以良好的收率和优异的非对映选择性和对映选择性获得各种咪唑烷衍生物。
