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高度取代咪唑烷合成的最新进展。

Recent advances in the synthesis of highly substituted imidazolidines.

作者信息

Olyaei Abolfazl, Sadeghpour Mahdieh

机构信息

Department of Chemistry, Faculty of Science, Imam Khomeini International University Qazvin Iran

Department of Chemistry, Qazvin Branch, Islamic Azad University Qazvin Iran.

出版信息

RSC Adv. 2024 Sep 26;14(42):30758-30806. doi: 10.1039/d4ra06010e. eCollection 2024 Sep 24.

DOI:10.1039/d4ra06010e
PMID:39328874
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11426194/
Abstract

Imidazolidine is a saturated heterocycle with a cyclic aminal core that can be found in natural products and biologically active molecules. Additionally, these heterocyclic compounds have been utilized as chiral ligands, N-heterocyclic carbene precursors, and catalysts in organic synthesis. This review is an attempt to compile the literature of various synthetic procedures of highly substituted imidazolidines, chiral imidazolidines with high diastereoselectivities and enantioselectivities, bis-imidazolidines, and spiro-imidazolidines, as well as their pharmacological properties during the period from 1949 to 2023.

摘要

咪唑烷是一种具有环状氨基核心的饱和杂环，存在于天然产物和生物活性分子中。此外，这些杂环化合物已被用作有机合成中的手性配体、N-杂环卡宾前体和催化剂。本综述旨在汇编1949年至2023年期间关于高度取代咪唑烷、具有高非对映选择性和对映选择性的手性咪唑烷、双咪唑烷和螺咪唑烷的各种合成方法及其药理性质的文献。

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本文引用的文献

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Front Chem. 2023 Sep 29;11:1272034. doi: 10.3389/fchem.2023.1272034. eCollection 2023.
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Synthesis of fused tetramate-oxazolidine and -imidazolidine derivatives and their antibacterial activity.稠合四氢呋喃-恶唑烷和-咪唑烷衍生物的合成及其抗菌活性。
Org Biomol Chem. 2023 Jun 14;21(23):4801-4809. doi: 10.1039/d3ob00594a.
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Copper-Catalyzed Heterocyclic Recombination of Aziridine and Diazetidine for the Synthesis of Imidazolidine.
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Chemistry. 2023 Aug 1;29(43):e202301071. doi: 10.1002/chem.202301071. Epub 2023 Jun 23.
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Stereospecific Single-Pot Route to Chiral Imidazolidines from Aziridines Using a 2D Cu Metal-Organic Framework.使用二维 Cu 金属有机骨架从氮丙啶立体选择性一锅法制备手性咪唑烷。
Inorg Chem. 2023 Mar 20;62(11):4540-4549. doi: 10.1021/acs.inorgchem.2c04443. Epub 2023 Mar 6.
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Enantioselective [3+2] Cycloaddition of Donor-Acceptor Aziridines and Imines to Construct 2,5-trans-Imidazolidines.给体-受体氮杂环丙烷与亚胺的对映选择性[3+2]环加成反应构建2,5-反式咪唑烷。
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