烟雾引起的表观基因组变化为致癌突变提供了有利条件。

Smoke-Induced Changes to the Epigenome Provide Fertile Ground for Oncogenic Mutation.

机构信息

Epigenetics Research Laboratory, Genomics and Epigenetics Division, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia; St. Vincent's Clinical School, UNSW Sydney, Sydney, NSW 1466, Australia.

CSIRO Health and Biosecurity, PO Box 52, North Ryde, NSW 1670, Australia.

出版信息

Cancer Cell. 2017 Sep 11;32(3):278-280. doi: 10.1016/j.ccell.2017.08.016.

DOI:10.1016/j.ccell.2017.08.016

PMID:28898692

Abstract

How genetic and epigenetic events synergize to generate the oncogenic state is not well understood. In this issue of Cancer Cell, Vaz et al. provide compelling evidence that exposure to chronic cigarette smoke causes progressive epigenetic alterations that prime for key genetic events to drive the development of lung cancer.

摘要

遗传和表观遗传事件如何协同作用产生致癌状态还不太清楚。在本期《癌细胞》杂志中，Vaz 等人提供了令人信服的证据，表明长期接触香烟烟雾会导致进行性表观遗传改变，从而为关键的遗传事件驱动肺癌的发展做好准备。