Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Key Laboratory of Hepatobiliary and Pancreatic Surgery and Digestive Organ Transplantation of Henan Province, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Front Immunol. 2023 Feb 17;14:1129298. doi: 10.3389/fimmu.2023.1129298. eCollection 2023.
As a prevalent epigenetic modification, the role of m6A has been increasingly highlighted in the alteration of numerous RNAs implicated with multiple biological processes, such as formation, export, translation, and degradation. With further the understanding of m6A, accumulating evidence shows that m6A modification similarly affects metabolic process of non-coding genes. But the specifical interplay of m6A and ncRNAs (non-coding RNAs) in gastrointestinal cancers still lacks complete discussion. Thus, we analyzed and summarized how ncRNAs affect the regulators of m6A and by what means the expression of ncRNAs is altered m6A in gastrointestinal cancers. We focused on the effect of the interaction of m6A and ncRNAs on the molecular mechanisms of malignant behavior in gastrointestinal cancers, revealing more possibilities of ncRNAs for diagnosis and treatment in term of epigenetic modification.
作为一种普遍的表观遗传修饰，m6A 的作用在涉及多种生物学过程的众多 RNA 的改变中越来越受到重视，如形成、输出、翻译和降解。随着对 m6A 的进一步了解，越来越多的证据表明，m6A 修饰同样影响非编码基因的代谢过程。但是，m6A 和非编码 RNA（ncRNA）在胃肠道癌症中的特异性相互作用仍缺乏完整的讨论。因此，我们分析和总结了 ncRNA 如何影响 m6A 的调节剂，以及 ncRNA 的表达如何改变胃肠道癌症中的 m6A。我们专注于 m6A 和 ncRNA 相互作用对胃肠道癌症恶性行为的分子机制的影响，从表观遗传修饰的角度揭示了 ncRNA 在诊断和治疗方面的更多可能性。
