Hajihashemi Saeed, Hamidizad Zeinab, Rahbari Ali, Ghanbari Fatemeh, Motealeghi Zohre Aghaee
Assistant professor of Physiology, Department of Physiology, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran.
MSc in Physiology, Arak University of Medical Sciences, Arak, Iran.
Drug Res (Stuttg). 2017 Dec;67(12):710-718. doi: 10.1055/s-0043-117418. Epub 2017 Sep 12.
The main side effect of gentamicin is nephrotoxicity. The effect of cobalamin (Cob) was investigated on gentamicin nephrotoxicity in rats. Renal injury induced by i.p. injection of gentamicin (100 mg/kg) for 8 consecutive days. Cobalamin (6 mg/kg/day, i.p) treatment was done for 8 consecutive days as co-treatment and post-treatment protocol. Cobalamin significantly increased creatinine clearance levels and renal blood flow which were reduced by gentamicin. Also, cobalamin significantly improved serum electrolytes (sodium and potassium) levels which were disturbed by gentamicin. Cobalamin significantly compensated deficits in the antioxidant defense mechanisms, suppressed lipid per oxidation and ameliorated renal tissue damage mediated by gentamicin. The results of the current study indicated that cobalamin effectively protected the kidney tissue against gentamicin induced acute nephrotoxicity in rats. The antioxidant and anti-inflammatory activities can be supposed the main factors responsible for the nephroprotective effect of cobalamin.
