Elder J S, Duckett J W, Snyder H M
Division of Urology, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine.
Lancet. 1987 Oct 31;2(8566):1007-10. doi: 10.1016/s0140-6736(87)92567-0.
The best management of fetal hydronephrosis is controversial. Despite the lack of experimental evidence that prenatal drainage of the obstructed urinary tract substantially improves ultimate renal function, various forms of percutaneous intervention on the fetal bladder and kidney have been used. To evaluate the efficacy of intervention for suspected fetal obstructive uropathy, all published reports of drainage of the fetal urinary tract up to December, 1985, were reviewed. In the 57 reported cases, the most common type of intervention was placement of a vesicoamniotic shunt (37%). Complications occurred in 25 cases (44%), including inadequate shunt drainage or migration (19%), onset of premature labour within 48 h (12%), urinary ascites (7%), and chorioamnionitis (5%). Of 28 fetuses with associated oligohydramnios, only 6 (21%) survived. 2 of these survivors had vesicoamniotic shunts, 2 single or multiple bladder aspirations, 1 an external renal drainage catheter, and 1 in-utero vesicostomy. Because of the high complication rate and lack of evidence of improved survival from in-utero drainage procedures, a prospective, randomised trial is needed to compare survival with and without vesicoamniotic shunt placement.
胎儿肾积水的最佳治疗方法存在争议。尽管缺乏实验证据表明对梗阻性尿路进行产前引流能显著改善最终肾功能,但人们已采用了多种形式的经皮胎儿膀胱和肾脏干预措施。为评估对疑似胎儿梗阻性肾病进行干预的疗效,我们回顾了截至1985年12月所有已发表的关于胎儿尿路引流的报告。在报告的57例病例中,最常见的干预类型是置入膀胱羊膜分流管(37%)。25例(44%)出现并发症,包括分流管引流不足或移位(19%)、48小时内早产(12%)、尿腹水(7%)和绒毛膜羊膜炎(5%)。在28例伴有羊水过少的胎儿中,仅有6例(21%)存活。这些存活者中,2例置入了膀胱羊膜分流管,2例进行了单次或多次膀胱穿刺抽吸,1例使用了外置肾引流导管,1例进行了宫内膀胱造口术。由于并发症发生率高且缺乏宫内引流手术能提高存活率的证据,因此需要进行一项前瞻性随机试验,以比较置入和未置入膀胱羊膜分流管的胎儿存活率。