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宫内经皮膀胱镜检查在胎儿下尿路梗阻性疾病管理中的应用

In-utero percutaneous cystoscopy in the management of fetal lower obstructive uropathy.

作者信息

Quintero R A, Johnson M P, Romero R, Smith C, Arias F, Guevara-Zuloaga F, Cotton D B, Evans M I

机构信息

Department of Obstetrics and Gynaecology, Hutzel Hospital/Wayne State University, Detroit, MI, USA.

出版信息

Lancet. 1995 Aug 26;346(8974):537-40. doi: 10.1016/s0140-6736(95)91381-5.

Abstract

In fetuses with lower obstructive uropathy, sonography cannot establish the cause of obstruction. We assessed whether percutaneous fetal cystoscopy could be useful in the evaluation and treatment of obstructive defects in utero. We inserted a fibreoptic endoscope through the lumen of the needle or trocar into the fetal bladder at the time of vesicocentesis or vesicoamniotic-shunt placement and looked at the the urethra, bladder neck, and ureteral orifices. Urethral vesicoamniotic shunting was considered in suitable cases; otherwise a percutaneous shunt was inserted. Fetal cystoscopy was possible in 11 of 13 patients referred. The bladder mucosa appeared haemorrhagic or oedematous in three. The ureteral orifices were seen in 9/11 fetuses, dilation was seen in five, but was only suspected in two by ultrasound. Ureteral webs were noted in two other fetuses. Two of seven fetuses underwent urethral vesicoamniotic shunting; urethral patency was achieved with urethral probing alone in one fetus. The remaining four fetuses were shunted with a standard technique. Fetal cystoscopy helps define the underlying conditions responsible for sonographic findings of lower obstructive uropathy, and allows the introduction of new treatments.

摘要

在患有下尿路梗阻性疾病的胎儿中,超声检查无法确定梗阻的原因。我们评估了经皮胎儿膀胱镜检查在评估和治疗子宫内梗阻性缺陷方面是否有用。在进行膀胱穿刺术或膀胱羊膜分流置管时,我们将纤维内窥镜通过针或套管的内腔插入胎儿膀胱,观察尿道、膀胱颈和输尿管口。在合适的病例中考虑进行尿道膀胱羊膜分流术;否则插入经皮分流管。在转诊的13例患者中,11例成功进行了胎儿膀胱镜检查。3例患者的膀胱黏膜出现出血或水肿。在11例胎儿中有9例观察到输尿管口,5例发现扩张,但超声仅怀疑2例。另外2例胎儿发现输尿管蹼。7例胎儿中有2例行尿道膀胱羊膜分流术;1例胎儿仅通过尿道探查就实现了尿道通畅。其余4例胎儿采用标准技术进行分流。胎儿膀胱镜检查有助于明确导致下尿路梗阻性疾病超声表现的潜在病因,并允许引入新的治疗方法。

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