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Adaptive immune constraints on C. difficile vaccination.

作者信息

Lang Mark L, Shrestha Binu

机构信息

a Department of Microbiology and Immunology , University of Oklahoma Health Sciences Center , Oklahoma City , OK , USA.

出版信息

Expert Rev Vaccines. 2017 Nov;16(11):1053-1055. doi: 10.1080/14760584.2017.1379397. Epub 2017 Sep 19.

DOI:10.1080/14760584.2017.1379397
PMID:28899198
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6072257/
Abstract
摘要

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本文引用的文献

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Mucosal Antibodies to the C Terminus of Toxin A Prevent Colonization of Clostridium difficile.针对毒素A C末端的黏膜抗体可预防艰难梭菌的定植。
Infect Immun. 2017 Mar 23;85(4). doi: 10.1128/IAI.01060-16. Print 2017 Apr.
2
Development of a Novel Vaccine Containing Binary Toxin for the Prevention of Clostridium difficile Disease with Enhanced Efficacy against NAP1 Strains.开发一种含二元毒素的新型疫苗，用于预防艰难梭菌疾病，对NAP1菌株具有更高疗效。
PLoS One. 2017 Jan 26;12(1):e0170640. doi: 10.1371/journal.pone.0170640. eCollection 2017.
3
Bezlotoxumab for Prevention of Recurrent Clostridium difficile Infection.贝洛妥珠单抗预防复发性艰难梭菌感染。
N Engl J Med. 2017 Jan 26;376(4):305-317. doi: 10.1056/NEJMoa1602615.
4
Human immune system variation.人类免疫系统变异。
Nat Rev Immunol. 2017 Jan;17(1):21-29. doi: 10.1038/nri.2016.125. Epub 2016 Dec 5.
5
A Clostridium difficile Cell Wall Glycopolymer Locus Influences Bacterial Shape, Polysaccharide Production and Virulence.艰难梭菌细胞壁糖聚合物基因座影响细菌形态、多糖产生及毒力。
PLoS Pathog. 2016 Oct 14;12(10):e1005946. doi: 10.1371/journal.ppat.1005946. eCollection 2016 Oct.
6
Safety, immunogenicity and dose response of VLA84, a new vaccine candidate against Clostridium difficile, in healthy volunteers.新型艰难梭菌疫苗候选物VLA84在健康志愿者中的安全性、免疫原性和剂量反应。
Vaccine. 2016 May 17;34(23):2585-92. doi: 10.1016/j.vaccine.2016.03.098. Epub 2016 Apr 11.
7
Defining the optimal formulation and schedule of a candidate toxoid vaccine against Clostridium difficile infection: A randomized Phase 2 clinical trial.确定一种针对艰难梭菌感染的候选类毒素疫苗的最佳配方和接种方案：一项随机2期临床试验。
Vaccine. 2016 Apr 27;34(19):2170-8. doi: 10.1016/j.vaccine.2016.03.028. Epub 2016 Mar 21.
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Memory B Cells Encode Neutralizing Antibody Specific for Toxin B from the Clostridium difficile Strains VPI 10463 and NAP1/BI/027 but with Superior Neutralization of VPI 10463 Toxin B.记忆B细胞编码针对艰难梭菌菌株VPI 10463和NAP1/BI/027毒素B的中和抗体，但其对VPI 10463毒素B的中和作用更强。
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9
Carbohydrate-Based Vaccines: An Overview.基于碳水化合物的疫苗：概述
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Prevalence and pathogenicity of binary toxin-positive Clostridium difficile strains that do not produce toxins A and B.不产生毒素A和毒素B的二元毒素阳性艰难梭菌菌株的流行情况和致病性
New Microbes New Infect. 2014 Nov 8;3:12-7. doi: 10.1016/j.nmni.2014.10.003. eCollection 2015 Jan.