Steinke Johanna, Gaser Christian, Langbein Kerstin, Dietzek Maren, Gussew Alexander, Reichenbach Jürgen R, Smesny Stefan, Sauer Heinrich, Nenadić Igor
Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany.
Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany; Department of Neurology, Jena University Hospital, Jena, Germany.
Brain Res. 2017 Dec 15;1677:14-19. doi: 10.1016/j.brainres.2017.09.004. Epub 2017 Sep 9.
Hippocampal structural and functional integrity impacts on multiple remote areas of the brain, and this connectivity is central to multiple cognitive functions in healthy and disease. We studied associations of hippocampal metabolic markers N-acetyl aspartate (NAA) and glutamate (Glu and Glx; assessed with 1H magnetic resonance spectroscopy) and brain grey matter (studied with voxel-based morphometry, VBM) in 20 healthy subjects. We found a significant correlation between right hippocampal NAA and left ventrolateral prefrontal cortical grey matter (TFCE, p<0.05, FWE-corrected), as well as verbal fluency markers, and right hippocampal Glx (glutamate/glutamine) and left cerebellar volume. Our studies demonstrate a structure-function correlation that might underlie the interaction of the hippocampus with prefrontal cortex and cerebellum, which might be central to several neurological and psychiatric disorders, including schizophrenia or depression.
海马体的结构和功能完整性会影响大脑的多个远程区域，并且这种连接性对于健康和疾病状态下的多种认知功能至关重要。我们研究了20名健康受试者中海马体代谢标志物N-乙酰天门冬氨酸（NAA）和谷氨酸（Glu和Glx；通过1H磁共振波谱评估）与脑灰质（采用基于体素的形态测量法，即VBM进行研究）之间的关联。我们发现右侧海马体NAA与左侧腹外侧前额叶皮质灰质（经TFCE校正，p<0.05，FWE校正）以及言语流畅性标志物之间存在显著相关性，同时右侧海马体Glx（谷氨酸/谷氨酰胺）与左侧小脑体积之间也存在显著相关性。我们的研究表明了一种结构-功能相关性，这种相关性可能是海马体与前额叶皮质及小脑相互作用的基础，而这可能是包括精神分裂症或抑郁症在内的多种神经和精神疾病的核心所在。
