小儿脑癌患者维生素D受体基因多态性的研究

Investigation of Vitamin D Receptor Gene Polymorphism in Pediatric Patients with Brain Cancer.

作者信息

Yilmaz Baris, Tokuc Gulnur Ayse, Koc Ahmet, Yesil Edanur

机构信息

Division of Paediatric Hematology and Oncology, Marmara University Education and Research Hospital, Istanbul, Turkey.

Division of General Paediatrics, Marmara University Education and Research Hospital, Istanbul, Turkey.

出版信息

Indian J Med Paediatr Oncol. 2017 Apr-Jun;38(2):128-132. doi: 10.4103/ijmpo.ijmpo_22_16.

DOI:10.4103/ijmpo.ijmpo_22_16

PMID:28900319

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5582548/

Abstract

AIM

In recent years, it is believed that Vitamin D may play a protective role in some cancer types. Certain regions of the Vitamin D receptor (VDR) gene may show a genetic difference in structure. The most frequent polymorphisms in this gene are in Taq-1, Fok-1, and Bsm-1 regions. Some adult cancer types are associated with VDR gene polymorphism such as; colorectal carcinoma, breast carcinoma, and prostate carcinoma. Reviewing the medical literature, no such study had been done on children so far.

MATERIALS AND METHODS

We investigated the association of the three most common gene polymorphisms (Taq-1, Fok-1, and Bsm-1 regions) in VDR gene in 32 children with brain tumors and forty control healthy volunteers.

RESULTS

We could not find any relationship between childhood brain tumors and VDR gene polymorphism in these three regions.

CONCLUSION

The present results suggest that the Taq-1, Fok-1, and Bsm-1 polymorphism in the VDR gene and pediatric brain cancers have no association.

摘要

目的

近年来，人们认为维生素D可能在某些癌症类型中发挥保护作用。维生素D受体（VDR）基因的某些区域可能存在结构上的遗传差异。该基因最常见的多态性存在于Taq-1、Fok-1和Bsm-1区域。一些成人癌症类型与VDR基因多态性有关，如结直肠癌、乳腺癌和前列腺癌。查阅医学文献，目前尚未对儿童进行过此类研究。