亚甲基四氢叶酸还原酶、维生素 D 受体和白细胞介素-16 基因多态性与肾细胞癌风险的关联。
Association of Methylenetetrahydrofolate Reductase, Vitamin D Receptor, and Interleukin-16 Gene Polymorphisms With Renal Cell Carcinoma Risk.
机构信息
1 Department of Nephrology, the Second Affiliated Hospital of Shantou University Medical College, Shantou, China.
2 Department of Nephrology, Huadu District People's Hospital of Guangzhou, Southern Medical University, Guangzhou, China.
出版信息
Technol Cancer Res Treat. 2019 Jan 1;18:1533033819859413. doi: 10.1177/1533033819859413.
In this meta-analysis, we investigated the association of methylenetetrahydrofolate reductase, vitamin D receptor, and interleukin-16 gene polymorphisms with the risk of renal cell carcinoma. We searched the PubMed and Cochrane Library databases up to July 1, 2017, and included 12 eligible case-control studies in our analysis. The vitamin D receptor ApaI A allele, ApaI AA and aa genotypes, BsmI B allele, and Fok1 FF genotype were all associated with the risk of renal cell carcinoma in Asian populations. However, methylenetetrahydrofolate reductase (rs1801133 and rs1801131), vitamin D receptor (TaqI and Fok1), and interleukin-16 (rs4778889 and rs11556218) gene polymorphisms were not associated with the risk of renal cell carcinoma. Our study indicates that the vitamin D receptor ApaI A allele, ApaI AA and aa genotypes, BsmI B allele, and Fok1 FF genotype are associated with renal cell carcinoma risk.
在这项荟萃分析中，我们研究了亚甲基四氢叶酸还原酶、维生素 D 受体和白细胞介素-16 基因多态性与肾细胞癌风险的关联。我们检索了 PubMed 和 Cochrane Library 数据库，截至 2017 年 7 月 1 日，并纳入了 12 项符合条件的病例对照研究。维生素 D 受体 ApaI A 等位基因、ApaI AA 和 aa 基因型、BsmI B 等位基因和 Fok1 FF 基因型均与亚洲人群肾细胞癌的风险相关。然而，亚甲基四氢叶酸还原酶（rs1801133 和 rs1801131）、维生素 D 受体（TaqI 和 Fok1）和白细胞介素-16（rs4778889 和 rs11556218）基因多态性与肾细胞癌的风险无关。我们的研究表明，维生素 D 受体 ApaI A 等位基因、ApaI AA 和 aa 基因型、BsmI B 等位基因和 Fok1 FF 基因型与肾细胞癌风险相关。
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