• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

沙棘糊通过减轻氧化应激来保护脂多糖诱导的小鼠急性肺损伤。

Seabuckthorn Paste Protects Lipopolysaccharide-Induced Acute Lung Injury in Mice through Attenuation of Oxidative Stress.

机构信息

College of Ethnomedicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China.

College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.

出版信息

Oxid Med Cell Longev. 2017;2017:4130967. doi: 10.1155/2017/4130967. Epub 2017 Aug 16.

DOI:10.1155/2017/4130967
PMID:28900533
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5576421/
Abstract

Oxidative stress is one of the major mechanisms implicated in endotoxin-induced acute lung injury. Seabuckthorn paste (SP), a traditional Tibetan medicine with high content of polyphenols and remarkable antioxidant activity, is commonly used in treating pulmonary diseases. In the present study, the protective effects and possible underlying mechanisms of SP on lipopolysaccharide- (LPS-) induced acute lung injury in mice were investigated. It was found that body weight loss, lung tissue microstructure lesions, transvascular leakage increase, malondialdehyde augmentation, and the reduction of superoxide dismutase and glutathione peroxidase levels caused by LPS challenge were all consistently relieved by SP treatment in a dose-dependent manner. Moreover, accumulation of nuclear factor erythroid 2-related factor 2 (Nrf2) in lung nuclei caused by SP treatment was observed. Our study demonstrated that SP can provide significant protection against LPS-induced acute lung injury through maintaining redox homeostasis, and its mechanism involves Nrf2 nuclear translocation and activation.

摘要

氧化应激是内毒素诱导急性肺损伤的主要机制之一。沙棘糊（SP）是一种传统的藏药，具有高含量的多酚和显著的抗氧化活性，常用于治疗肺部疾病。在本研究中，研究了 SP 对脂多糖（LPS）诱导的小鼠急性肺损伤的保护作用及其可能的作用机制。结果发现，SP 处理可剂量依赖性地减轻 LPS 引起的体重减轻、肺组织微观结构损伤、跨血管渗漏增加、丙二醛增加以及超氧化物歧化酶和谷胱甘肽过氧化物酶水平降低。此外，还观察到 SP 处理导致核因子红细胞 2 相关因子 2（Nrf2）在肺核中的积累。本研究表明，SP 通过维持氧化还原平衡对 LPS 诱导的急性肺损伤提供显著保护，其机制涉及 Nrf2 核易位和激活。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/861c/5576421/5ba9e8c6a978/OMCL2017-4130967.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/861c/5576421/41f767695a18/OMCL2017-4130967.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/861c/5576421/db60b42cdf1c/OMCL2017-4130967.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/861c/5576421/a085272c1a6f/OMCL2017-4130967.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/861c/5576421/0d800b82bf24/OMCL2017-4130967.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/861c/5576421/8077b5b9dc83/OMCL2017-4130967.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/861c/5576421/5ba9e8c6a978/OMCL2017-4130967.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/861c/5576421/41f767695a18/OMCL2017-4130967.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/861c/5576421/db60b42cdf1c/OMCL2017-4130967.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/861c/5576421/a085272c1a6f/OMCL2017-4130967.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/861c/5576421/0d800b82bf24/OMCL2017-4130967.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/861c/5576421/8077b5b9dc83/OMCL2017-4130967.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/861c/5576421/5ba9e8c6a978/OMCL2017-4130967.006.jpg

相似文献

1
Seabuckthorn Paste Protects Lipopolysaccharide-Induced Acute Lung Injury in Mice through Attenuation of Oxidative Stress.沙棘糊通过减轻氧化应激来保护脂多糖诱导的小鼠急性肺损伤。
Oxid Med Cell Longev. 2017;2017:4130967. doi: 10.1155/2017/4130967. Epub 2017 Aug 16.
2
Febuxostat protects rats against lipopolysaccharide-induced lung inflammation in a dose-dependent manner.非布司他以剂量依赖的方式保护大鼠免受脂多糖诱导的肺部炎症。
Naunyn Schmiedebergs Arch Pharmacol. 2016 Mar;389(3):269-78. doi: 10.1007/s00210-015-1202-6. Epub 2015 Dec 28.
3
Tempol, a membrane-permeable radical scavenger, ameliorates lipopolysaccharide-induced acute lung injury in mice: a key role for superoxide anion.替普瑞醇，一种膜通透性自由基清除剂，可改善脂多糖诱导的小鼠急性肺损伤：超氧阴离子的关键作用。
Eur J Pharmacol. 2011 Aug 1;663(1-3):68-73. doi: 10.1016/j.ejphar.2011.04.054. Epub 2011 May 1.
4
The protective effect of Trillin LPS-induced acute lung injury by the regulations of inflammation and oxidative state.Trillin通过调节炎症和氧化状态对脂多糖诱导的急性肺损伤具有保护作用。
Chem Biol Interact. 2016 Jan 5;243:127-34. doi: 10.1016/j.cbi.2015.09.010. Epub 2015 Sep 9.
5
Xanthohumol ameliorates lipopolysaccharide (LPS)-induced acute lung injury via induction of AMPK/GSK3β-Nrf2 signal axis.黄腐酚通过诱导AMPK/GSK3β-Nrf2信号轴改善脂多糖（LPS）诱导的急性肺损伤。
Redox Biol. 2017 Aug;12:311-324. doi: 10.1016/j.redox.2017.03.001. Epub 2017 Mar 2.
6
Protective effects of pogostone against LPS-induced acute lung injury in mice via regulation of Keap1-Nrf2/NF-κB signaling pathways.广藿香酮通过调控Keap1-Nrf2/NF-κB信号通路对脂多糖诱导的小鼠急性肺损伤的保护作用
Int Immunopharmacol. 2016 Mar;32:55-61. doi: 10.1016/j.intimp.2016.01.007. Epub 2016 Jan 19.
7
Usnic acid protects LPS-induced acute lung injury in mice through attenuating inflammatory responses and oxidative stress.松萝酸通过减轻炎症反应和氧化应激来保护脂多糖诱导的小鼠急性肺损伤。
Int Immunopharmacol. 2014 Oct;22(2):371-8. doi: 10.1016/j.intimp.2014.06.043. Epub 2014 Jul 26.
8
Inhibition of nuclear factor-κB signal by pyrrolidine dithiocarbamate alleviates lipopolysaccharide-induced acute lung injury.吡咯烷二硫代氨基甲酸盐对核因子-κB信号的抑制作用可减轻脂多糖诱导的急性肺损伤。
Oncotarget. 2017 Jul 18;8(29):47296-47304. doi: 10.18632/oncotarget.17624.
9
Kegan Liyan oral liquid ameliorates lipopolysaccharide-induced acute lung injury through inhibition of TLR4-mediated NF-κB signaling pathway and MMP-9 expression.克甘利咽口服液通过抑制TLR4介导的NF-κB信号通路和MMP-9表达改善脂多糖诱导的急性肺损伤。
J Ethnopharmacol. 2016 Jun 20;186:91-102. doi: 10.1016/j.jep.2016.03.057. Epub 2016 Mar 30.
10
Seabuckthorn berry polysaccharide protects against carbon tetrachloride-induced hepatotoxicity in mice via anti-oxidative and anti-inflammatory activities.沙棘浆果多糖通过抗氧化和抗炎活性保护小鼠免受四氯化碳诱导的肝毒性。
Food Funct. 2017 Sep 20;8(9):3130-3138. doi: 10.1039/c7fo00399d.

引用本文的文献

1
Protective Effects of Rhizoma on Lipopolysaccharide-Induced Acute Lung Injury via TLR4/NF-κB and Keap1/Nrf2 Signaling Pathways In Vitro and In Vivo.体外和体内研究姜黄根茎对 TLR4/NF-κB 和 Keap1/Nrf2 信号通路介导的脂多糖诱导的急性肺损伤的保护作用。
Int J Mol Sci. 2022 Dec 17;23(24):16134. doi: 10.3390/ijms232416134.
2
GPA Peptide Attenuates Sepsis-Induced Acute Lung Injury in Mice via Inhibiting Oxidative Stress and Pyroptosis of Alveolar Macrophage.GPA 肽通过抑制肺泡巨噬细胞氧化应激和焦亡减轻小鼠脓毒症性急性肺损伤。
Oxid Med Cell Longev. 2021 Dec 28;2021:5589472. doi: 10.1155/2021/5589472. eCollection 2021.
3

本文引用的文献

1
Nrf2 in health and disease: current and future clinical implications.Nrf2在健康与疾病中的作用：当前及未来的临床意义
Clin Sci (Lond). 2015 Dec;129(12):989-99. doi: 10.1042/CS20150436.
2
Protective Effect of Isorhamnetin on Lipopolysaccharide-Induced Acute Lung Injury in Mice.异鼠李素对脂多糖诱导的小鼠急性肺损伤的保护作用
Inflammation. 2016 Feb;39(1):129-137. doi: 10.1007/s10753-015-0231-0.
3
High altitude and free radicals.高海拔与自由基。
Protection of ripasudil, a Rho kinase inhibitor, in lipopolysaccharides-induced acute pneumonia in mice.
Rho激酶抑制剂法舒地尔对脂多糖诱导的小鼠急性肺炎的保护作用。
Am J Transl Res. 2019 Oct 15;11(10):6433-6443. eCollection 2019.
4
[Protective effect of dexmedetomidine against perioperative inflammation and on pulmonary function in patients undergoing radical resection of lung cancer].右美托咪定对肺癌根治术患者围手术期炎症及肺功能的保护作用
Nan Fang Yi Ke Da Xue Xue Bao. 2017 Dec 20;37(12):1673-1677. doi: 10.3969/j.issn.1673-4254.2017.12.19.
J Sports Sci Med. 2004 Jun 1;3(2):64-9. eCollection 2004 Jun.
4
Curcumin ameloriates heat stress via inhibition of oxidative stress and modulation of Nrf2/HO-1 pathway in quail.姜黄素通过抑制氧化应激和调节 Nrf2/HO-1 通路缓解鹌鹑的热应激。
Food Chem Toxicol. 2012 Nov;50(11):4035-41. doi: 10.1016/j.fct.2012.08.029. Epub 2012 Aug 23.
5
Nrf2:INrf2 (Keap1) signaling in oxidative stress.Nrf2：氧化应激中的Nrf2：INrf2（Keap1）信号传导
Free Radic Biol Med. 2009 Nov 1;47(9):1304-9. doi: 10.1016/j.freeradbiomed.2009.07.035. Epub 2009 Aug 7.
6
Examining the endogenous antioxidant response through immunofluorescent analysis of Nrf2 in tissue.通过组织中Nrf2的免疫荧光分析来检测内源性抗氧化反应。
Methods Mol Biol. 2008;477:229-43. doi: 10.1007/978-1-60327-517-0_18.
7
Antioxidant and free radical scavenging activity of Spondias pinnata.阔叶破布木的抗氧化及自由基清除活性
BMC Complement Altern Med. 2008 Dec 9;8:63. doi: 10.1186/1472-6882-8-63.
8
High altitude and oxidative stress.高海拔与氧化应激。
Respir Physiol Neurobiol. 2007 Sep 30;158(2-3):128-31. doi: 10.1016/j.resp.2007.03.013. Epub 2007 Mar 31.
9
Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway.细胞通过Keap1-Nrf2-ARE途径对环境应激的存活反应。
Annu Rev Pharmacol Toxicol. 2007;47:89-116. doi: 10.1146/annurev.pharmtox.46.120604.141046.
10
Elemental and nutritional analysis of sea buckthorn (Hippophae rhamnoides ssp. turkestanica) Berries of Pakistani origin.巴基斯坦产沙棘（突厥沙棘亚种）果实的元素与营养分析
J Med Food. 2005 Winter;8(4):518-22. doi: 10.1089/jmf.2005.8.518.