Kheifets Leeka, Crespi Catherine M, Hooper Chris, Cockburn Myles, Amoon Aryana T, Vergara Ximena P
Department of Epidemiology, UCLA Fielding School of Public Health, 650 Charles E Young Drive South, Los Angeles, CA, 90024, USA.
Department of Biostatistics, UCLA Fielding School of Public Health, Los Angeles, CA, 90024, USA.
Cancer Causes Control. 2017 Oct;28(10):1117-1123. doi: 10.1007/s10552-017-0951-6. Epub 2017 Sep 12.
Studies have reported an increased risk of childhood leukemia associated with exposure to magnetic fields. We conducted a large records-based case-control study of childhood leukemia risk and exposure to magnetic fields from power lines in California.
The study included 5,788 childhood leukemia cases (born in and diagnosed in California 1986-2008) matched to population-based controls on age and sex. We calculated magnetic fields at birth addresses using geographic information systems, aerial imagery, historical information on load and phasing, and site visits.
Based on unconditional logistic regression controlling for age, sex, race/ethnicity, and socioeconomic status using subjects geocoded to a basic standard of accuracy, we report a slight risk deficit in two intermediate exposure groups and a small excess risk in the highest exposure group (odds ratio of 1.50 (95% confidence interval [0.70, 3.23])). Subgroup and sensitivity analyses as well as matched analyses gave similar results. All estimates had wide confidence intervals.
Our large, statewide, record-based case-control study of childhood leukemia in California does not in itself provide clear evidence of risk associated with greater exposure to magnetic fields from power lines, but could be viewed as consistent with previous findings of increased risk.
研究报告称，儿童接触磁场会增加患白血病的风险。我们在加利福尼亚州开展了一项基于大量记录的病例对照研究，以探讨儿童白血病风险与输电线磁场暴露之间的关系。
该研究纳入了5788例儿童白血病病例（1986年至2008年在加利福尼亚州出生并确诊），并根据年龄和性别与基于人群的对照组进行匹配。我们使用地理信息系统、航空图像、负荷和相位的历史信息以及实地考察来计算出生地址的磁场。
基于无条件逻辑回归，使用地理编码至基本准确标准的受试者，控制年龄、性别、种族/民族和社会经济地位，我们报告了两个中等暴露组的风险略有不足，以及最高暴露组的风险略有增加（比值比为1.50（95%置信区间[0.70, 3.23]））。亚组分析、敏感性分析以及匹配分析得出了相似的结果。所有估计值的置信区间都很宽。
我们在加利福尼亚州开展的这项基于大量记录的全州范围儿童白血病病例对照研究本身并未提供明确证据表明，接触更多输电线磁场会带来风险，但可被视为与先前风险增加的研究结果一致。
