暴露于极低频电磁场与儿童癌症：系统评价与荟萃分析。
Exposure to extremely low-frequency magnetic fields and childhood cancer: A systematic review and meta-analysis.
机构信息
College of Nursing, Korea University, BK21FOUR R&E Center for Learning Health Systems, Korea University, Seoul, Republic of Korea.
Department of Biostatistics, College of Medicine, Korea University, BK21FOUR Program in Learning Health Systems, Korea University, Seoul, Republic of Korea.
出版信息
PLoS One. 2021 May 14;16(5):e0251628. doi: 10.1371/journal.pone.0251628. eCollection 2021.
BACKGROUND
Extremely low frequency magnetic fields (ELF-MFs) are classified as a possible carcinogenic factor (Group 2B). This study assessed the association between ELF-MFs and childhood cancer through a systematic review and meta-analysis.
METHODS
Three databases were searched in January 2020. We conducted a meta-analysis for the association between the ELF-MFs exposure level and childhood cancer.
RESULTS
A total of 33 studies were identified. Thirty studies with 186,223 participants were included in the meta-analysis. Children exposed to 0.2-, 0.3-, and 0.4-μT ELF-MFs had a 1.26 (95% confidence interval [CI] 1.06-1.49), 1.22 (95% CI 0.93-1.61), and 1.72 (95% CI 1.25-2.35) times higher odds of childhood leukemia. In childhood brain tumors, children exposed to 0.2-μT had a 0.95 (95% CI 0.59-1.56) times higher odds, and those exposed to 0.4-μT ELF-MFs had a 1.25 (95% CI 0.93-1.61). Children exposed to 0.2- and 0.4-μT ELF-MFs had a 1.10 (95% CI 0.70-1.75) and 2.01 (95% CI 0.89-4.52) times higher odds of any childhood cancers.
CONCLUSIONS
Significant associations were observed between exposure to ELF-MFs and childhood leukemia. Furthermore, a possible dose-response effect was also observed.
背景
极低频磁场（ELF-MFs）被归类为可能的致癌因素（2B 组）。本研究通过系统评价和荟萃分析评估了 ELF-MFs 与儿童癌症之间的关联。
方法
2020 年 1 月，我们在三个数据库中进行了检索。我们对 ELF-MFs 暴露水平与儿童癌症之间的关联进行了荟萃分析。
结果
共确定了 33 项研究。共有 30 项研究纳入了 186223 名参与者，其中 22 项研究纳入了儿童白血病，8 项研究纳入了儿童脑瘤。荟萃分析结果显示，暴露于 0.2、0.3 和 0.4μT ELF-MFs 的儿童患儿童白血病的风险分别增加了 1.26（95%置信区间 1.06-1.49）、1.22（95%置信区间 0.93-1.61）和 1.72（95%置信区间 1.25-2.35）倍。在儿童脑瘤中，暴露于 0.2μT 的儿童患脑瘤的风险增加了 0.95（95%置信区间 0.59-1.56）倍，而暴露于 0.4μT ELF-MFs 的儿童患脑瘤的风险增加了 1.25（95%置信区间 0.93-1.61）倍。暴露于 0.2μT 和 0.4μT ELF-MFs 的儿童患任何儿童癌症的风险分别增加了 1.10（95%置信区间 0.70-1.75）和 2.01（95%置信区间 0.89-4.52）倍。
结论
ELF-MFs 暴露与儿童白血病之间存在显著关联，并且可能存在剂量-反应关系。
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