Chan Y C, Wong T W, Yap E H, Tan H C, Lee H W, Chu Y K, Lee P W
Department of Microbiology, Faculty of Medicine, National University of Singapore.
Med J Aust. 1987 Sep 7;147(5):248-9. doi: 10.5694/j.1326-5377.1987.tb133422.x.
A case of haemorrhagic fever with renal syndrome that originated in Malaysia is reported. The patient presented with clinical symptoms which were not typical of the disease as seen in endemic regions. Renal involvement, which is characteristic of haemorrhagic fever with renal syndrome, was mild, and the predominant symptom was a persistently marked elevation of serum transaminase levels that was suggestive of hepatitis. Liver involvement has not been described in the Asian form of haemorrhagic fever with renal syndrome. The patient developed a petechial skin rash and had severe thrombocytopenia. Serological confirmation of the diagnosis of haemorrhagic fever with renal syndrome was obtained by the demonstration of significant antibody rises to hantaviruses in the patient's acute- and convalescent-phase sera.
报告了一例起源于马来西亚的肾综合征出血热病例。患者表现出的临床症状并非流行地区所见该疾病的典型症状。肾综合征出血热的特征性表现即肾脏受累情况较轻，主要症状是血清转氨酶水平持续显著升高，提示肝炎。亚洲型肾综合征出血热中尚未有肝脏受累的描述。该患者出现了瘀点性皮疹且有严重血小板减少症。通过检测患者急性期和恢复期血清中针对汉坦病毒的抗体显著升高，血清学确诊了肾综合征出血热。
