Zeng Rong-Gui, Jiang Qie-Ying, Liao Zheng-Gen, Zhao Guo-Wei, Luo Yun, Luo Juan, Lv Dan
Key Laboratory of Modern Preparation of Chinese Materia Medica, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China.
School of Continuing Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China.
Zhongguo Zhong Yao Za Zhi. 2016 Jun;41(12):2245-2249. doi: 10.4268/cjcmm20161212.
To study the improvement of powder flowability and hygroscopicity of traditional Chinese medicine extract by surface coating modification technology. The 1% hydrophobic silica nanoparticles were used as surface modifier, and andrographis extract powder was taken as a model drug. Three different techniques were used for coating model drugs, with angle of repose, compressibility, flat angle and cohesion as the comprehensive evaluation indexes for the powder flowability. The powder particle size and the size distribution were measured by Mastersizer 2000. FEI scanning electron microscope was used to observe the surface morphology and structure of the powder. The percentage of Si element on the powder surface was measured by energy dispersive spectrometer. The hygroscopicity of powder was determined by Chinese pharmacopoeia method. All of the three techniques can improve the flowability of powder extract. In particular, hygroscopicity of extract powder can also be improved by dispersion and then high-speed mixing, which can produce a higher percentage of Si element on the powder surface. The improvement principle may be correlated with a modifier adhered to the powder surface.
研究表面包覆改性技术对中药提取物粉体流动性和吸湿性的改善作用。以1%疏水性二氧化硅纳米粒子作为表面改性剂，穿心莲提取物粉为模型药物。采用三种不同技术对模型药物进行包覆，以休止角、压缩度、扁平角和凝聚力作为粉体流动性的综合评价指标。用Mastersizer 2000测定粉体粒度及粒度分布。采用FEI扫描电子显微镜观察粉体的表面形态和结构。用能谱仪测定粉体表面Si元素的含量。按照《中国药典》方法测定粉体的吸湿性。三种技术均能提高提取物粉体的流动性。尤其是通过分散后高速混合，提取物粉体的吸湿性也可得到改善，且粉体表面可产生较高比例的Si元素。改善原理可能与改性剂附着于粉体表面有关。
