Dai Yun-Hao, Wang Man, Ju Jian-Ming, Zhang Zhen-Hai
Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing 210000, China.
Institute of Chinese Medicine in Jiangsu Province, Nanjing 210028, China.
Zhongguo Zhong Yao Za Zhi. 2016 Jun;41(12):2250-2254. doi: 10.4268/cjcmm20161213.
In this study, magnolol phospholipid complex (MPC) was prepared and solidified with polyvingypyrrolidone (PVPP). The influence of PVPP on MPC's flowability, dissolution and oral bioavailability was investigated. The results of phase characterization using differential scanning calorimetry (DSC), infrared spectroscopy (IR), and scanning electron microscopy (SEM) showed that magnolol existed in solidified powder and MPC in an amorphous state. In flowability and dissolution experiments, solidified powder showed significant superiority. At the same time, it showed a higher oral bioavailability compared with MPC, with AUC0-∞ of 73.47 μg•h•mL⁻¹ vs. 63.48 μg•h•mL⁻¹. This process for solidifying powder with PVPP is simple and convenient.
在本研究中，制备了厚朴酚磷脂复合物（MPC）并用聚乙烯吡咯烷酮（PVPP）进行固化。研究了PVPP对MPC流动性、溶解性和口服生物利用度的影响。使用差示扫描量热法（DSC）、红外光谱（IR）和扫描电子显微镜（SEM）进行相表征的结果表明，厚朴酚以非晶态存在于固化粉末和MPC中。在流动性和溶解实验中，固化粉末表现出显著优势。同时，与MPC相比，其口服生物利用度更高，AUC0-∞分别为73.47μg•h•mL⁻¹和63.48μg•h•mL⁻¹。用PVPP固化粉末的这个过程简单方便。
