Zhang Xiao-Bo, Zhao Yu-Ping, Huang Xiao-Wei, Qiu Zhi-Dong, Guo Lan-Ping, Qu Xiao-Bo, Huang Lu-Qi
State Key Laboratory Breeding Base of Dao-di Herbs, National Resource Center for Chinese Materia Medical, China Academy of Chinese Medical Sciences, Beijing 100700, China.
College of Pharmacy, Changchun University of Chinese Medicine, Changchun 130117, China.
Zhongguo Zhong Yao Za Zhi. 2016 Jun;41(11):2015-2018. doi: 10.4268/cjcmm20161107.
Artemisiae Annuae Herba has used as a medicine for more than 2 000 years. To infer based on the modern study results, Artemisiae Annuae Herba used for the treatment of malaria recorded in Zhou Hou Bei Ji Fang before 1 700 years should come from Artemisia annua. Based on the data of Chinese materia medica, from the field of treatment hotness and preventing attack of malaria etc., the Dao-di producing district of Artemisiae Annuae Herba should at Jingzhou (now Hubei) and surrounding areas in history. From the view of anti-malaria components artemisinin content, the Dao-di growing producing district of Artemisiae Annuae Herba should locate at Chongqing, Guangxi and its surrounding provinces. The study results showed that A. annua was harvested in flower bloom at autumn, and in this time it also had higher artemisinin content. If A. annua was stored exceed six months, artemisinin could be degraded about thirty percent. So it should be stored in a cool and dry place generally. Wild A. annua had a rich genetic diversity. Artemisinin content of A. annua breeding in experimental field could reache to two percent.
青蒿入药已有2000多年的历史。根据现代研究结果推断,1700年前《肘后备急方》中记载的用于治疗疟疾的青蒿应该来自黄花蒿。根据本草资料,从治疗发热和预防疟疾发作等方面来看,历史上青蒿的道地产区应该在荆州(今湖北)及其周边地区。从抗疟成分青蒿素含量来看,青蒿的道地种植产区应该位于重庆、广西及其周边省份。研究结果表明,黄花蒿在秋季花期采收,此时青蒿素含量也较高。如果黄花蒿储存超过6个月,青蒿素可能会降解约30%。所以一般应储存在阴凉干燥的地方。野生黄花蒿具有丰富的遗传多样性。实验田中培育的黄花蒿青蒿素含量可达2%。