钴催化的未活化烯烃与三氟甲磺酸亚钠和过氧氢的三氟甲基化-过氧化反应。
Cobalt-Catalyzed Trifluoromethylation-Peroxidation of Unactivated Alkenes with Sodium Trifluoromethanesulfinate and Hydroperoxide.
机构信息
School of Chemical Engineering and Technology, Hebei University of Technology , Tianjin 300130, P. R. China.
National-Local Joint Engineering Laboratory for Energy Conservation of Chemical Process Integration and Resources Utilization, Hebei University of Technology , Tianjin 300130, P. R. China.
出版信息
Org Lett. 2017 Oct 6;19(19):5260-5263. doi: 10.1021/acs.orglett.7b02353. Epub 2017 Sep 13.
Disclosed herein is an unprecedented cobalt-catalyzed trifluoromethylation-peroxidation of unactivated alkenes. In this process the hydroperoxide acts as a radical initiator as well as a coupling partner. The cheap and readily available sodium trifluoromethanesulfinate serves as the CF source in the reaction. Various alkenes are transformed into vicinal trifluoromethyl-peroxide compounds in moderate to good yields.
本文公开了一种前所未有的钴催化的未活化烯烃的三氟甲基化-过氧化反应。在这个过程中，过氧化物既是自由基引发剂，又是偶联试剂。廉价易得的三氟甲磺酸纳作为反应中的 CF 源。各种烯烃以中等至良好的收率转化为偕二氟甲基过氧化物化合物。
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