Colpaert Francis C, Bervoets Karin J W, Van den Hoogen Rob H W M
Department of Pharmacology, Janssen Pharmaceutica, B-2340 BeerseBelgium Diaconessenhuis, 2300 RD LeidenThe Netherlands.
Pain. 1987 Aug;30(2):243-258. doi: 10.1016/0304-3959(87)91080-3.
The study examined the validity of increased minute volume of ventilation as a measurement of chronic pain in arthritic rats. The opiates morphine and R 62 818 attenuated arthritic hyperventilation, but only at doses which also reduced the ventilatory response to CO2 in normal rats. The non-steroidal anti-inflammatory drugs (NSAIDs), indomethacin and suprofen, the corticosteroids, cortisone and dexamethasone, and the tranquillizers, haloperidol and chlordiazepoxide, were essentially ineffective except at doses that also produced anti-inflammatory and/or toxic effects. A combination of an in itself ineffective dose of R 62 818 with an ineffective dose of suprofen did attenuate arthritic hyperventilation, and the combination constituted the only pharmacological treatment that did so in the absence of anti-inflammatory, toxic or intrinsic respiratory effects. The data are consistent with the hypothesis that pain rather than acidosis mediates arthritic hyperventilation. They also suggest that combinations of an opiate with an NSAID may perhaps be effective in alleviating this pain.
该研究检验了增加每分钟通气量作为关节炎大鼠慢性疼痛指标的有效性。阿片类药物吗啡和R 62 818可减弱关节炎引起的通气过度，但仅在能降低正常大鼠对二氧化碳通气反应的剂量下才有效。非甾体抗炎药（NSAIDs）吲哚美辛和舒洛芬、皮质类固醇可的松和地塞米松以及镇静剂氟哌啶醇和氯氮卓基本上无效，除非达到产生抗炎和/或毒性作用的剂量。本身无效剂量的R 62 818与无效剂量的舒洛芬联合使用确实减弱了关节炎引起的通气过度，并且该联合用药是在没有抗炎、毒性或内在呼吸作用的情况下唯一能做到这一点的药物治疗方法。这些数据与疼痛而非酸中毒介导关节炎通气过度的假说一致。它们还表明，阿片类药物与NSAIDs联合使用可能有效缓解这种疼痛。
