Department of Intensive Care Unit of the Affiliated Nanhua Hospital, University of South China, Hengyang, China.
Eur J Clin Nutr. 2018 Jan;72(1):66-68. doi: 10.1038/ejcn.2017.139. Epub 2017 Sep 13.
Whether enteral nutrition (EN) is superior to parenteral nutrition (PN) in critically ill patients with severe acute pancreatitis remains unknown. The objective of this meta-analysis was to assess the effects of EN versus PN on clinical outcomes in a subgroup of pancreatitis patients. Relevant randomized controlled trials (RCTs) were searched in Scopus, PubMed and Web of Science from inception to August 2016. Ultimately, five RCTs including 348 patients were enrolled in this analysis. Compared with PN, EN was associated with a significant reduction in overall mortality (risk ratio (RR)=0.36, 95% confidence interval (CI) 0.20-0.65, P=0.001) and the rate of multiple organ failure (RR=0.39, 95% CI 0.21-0.73, P=0.003). EN should be recommended as the preferred route of nutrition for critically ill patients with severe acute pancreatitis.
对于伴有重症急性胰腺炎的危重症患者，肠内营养（EN）是否优于肠外营养（PN）仍不清楚。本荟萃分析的目的在于评估 EN 与 PN 对胰腺炎患者亚组的临床结局的影响。从 Scopus、PubMed 和 Web of Science 数据库中检索了截至 2016 年 8 月的相关随机对照试验（RCT）。最终，纳入了 5 项 RCT，共 348 例患者。与 PN 相比，EN 可显著降低总体死亡率（风险比（RR）=0.36，95%置信区间（CI）0.20-0.65，P=0.001）和多器官衰竭发生率（RR=0.39，95%CI 0.21-0.73，P=0.003）。对于伴有重症急性胰腺炎的危重症患者，EN 应被推荐为首选的营养途径。
