乙肝病毒学抑制：仍不足以预防肝细胞癌。一则长达15年的真实病例报告。

HBV virological suppression: still not enough to save from hepatocellular carcinoma. A case report on a 15-year, real-life story.

作者信息

Prestileo Tullio, Di Lorenzo Francesco, Sanfilippo Adriana, Imburgia Claudia, Cabibbo Giuseppe, Corrao Salvatore

机构信息

Department of Internal Medicine, National Hospital Trust, ARNAS Civico di Cristina e Benfratelli, Infection Unit, Palermo, Italy.

Section of Gastroenterology, DiBiMIS, University of Palermo, Italy.

出版信息

Recenti Prog Med. 2017 Sep;108(9):379-381. doi: 10.1701/2745.27990.

DOI:10.1701/2745.27990

PMID:28901347

Abstract

Among HIV-infected patients worldwide, 2-4 million are chronically infected with HBV. We report a 15-year, real-life story of a patient with HBV-HIV coinfection, who developed HCC despite high treatment adherence and complete viral suppression. The aim of our report is to alert the infectious diseases community to monitor the possible development of HCC regardless of high treatment adherence and complete viral suppression.

摘要

在全球感染艾滋病毒的患者中，有200万至400万人长期感染乙肝病毒。我们报告了一名乙肝和艾滋病毒合并感染患者的15年真实病例，该患者尽管治疗依从性高且病毒得到完全抑制，但仍发展为肝癌。我们报告的目的是提醒传染病学界，无论治疗依从性高且病毒得到完全抑制，都要监测肝癌的可能发展情况。