Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China.
Department of Pathology, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, Jiangsu 225000, P.R. China.
Mol Med Rep. 2017 Nov;16(5):6467-6471. doi: 10.3892/mmr.2017.7472. Epub 2017 Sep 12.
It is widely reported that long non‑coding RNAs (lncRNAs) are involved in regulating cell differentiation, proliferation, apoptosis and other biological processes. Certain lncRNAs have been found to be crucial in various types of tumor. Taurine‑upregulated gene 1 (TUG1) has been shown to be expressed in a tissue‑specific pattern and exert oncogenic or tumor suppressive functions in different types of cancer in humans. According to previous studies, TUG1 is predominantly located in the nucleus and may regulate gene expression at the transcriptional level. It mediates chromosomal remodeling and coordinates with polycomb repressive complex 2 (PRC2) to regulate gene expression. Although the mechanisms of how TUG1 affects the tumor genesis process remain to be fully elucidated, increasing studies have suggested that TUG1 offers potential as a diagnostic and prognostic biomarker, and as a therapeutic target in certain types of tumor. This review aims to summarize current evidence concerning the characteristics, mechanisms and associations with cancer of TUG1.
据广泛报道，长非编码 RNA（lncRNA）参与调节细胞分化、增殖、凋亡和其他生物学过程。某些 lncRNA 在各种类型的肿瘤中至关重要。牛磺酸上调基因 1（TUG1）的表达具有组织特异性，并在人类的不同类型癌症中发挥致癌或肿瘤抑制功能。根据之前的研究，TUG1 主要位于细胞核内，并可能在转录水平上调节基因表达。它介导染色质重塑，并与多梳抑制复合物 2（PRC2）协调以调节基因表达。尽管 TUG1 影响肿瘤发生过程的机制仍有待充分阐明，但越来越多的研究表明，TUG1 作为某些类型肿瘤的诊断和预后生物标志物以及治疗靶点具有潜力。本综述旨在总结目前关于 TUG1 的特征、机制及其与癌症的关联的证据。
